Lymphoid Regeneration Following x-Ray Treatment and the Susceptibility to the Induction of Immunological Tolerance
One of the main incentives for the study of the lymphoid system is its acknowledged role in the various manifestations of the immune response. The observations of Fishman (1961) suggest that antibody formation, at least, may depend on more than one cell type and that the lymphoid cells form antibody in response to instruction by macrophages. It would be tempting, therefore, to elucidate the possible function of these two cell series in other known immunological phenomena. The study reported here is an attempt to make some deductions along these lines with respect to the cellular basis of immunological tolerance.
KeywordsHuman Serum Albumin Antibody Formation Radiation Injury Tolerance Induction Immune Recovery
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- Gallily, R., and M. Feldman: The role of macrophages in the induction of antibody in x-irradiated animals. Immunology (in press). Also: this Sympsoium.Google Scholar
- Gordon, L. E., D. B. Cooper, and C. P. Miller: Clearance of bacteria from the blood of irradiated rabbits. Proc. Soc. exp. Biol. (N.Y.) 89, 577–579 (1955).Google Scholar
- Keuning, F. J., and W. H. Bos: Regeneration patterns of lymphoid follicles in the rabbit spleen after sublethal x-irradiation. This Symposium.Google Scholar
- Silverman, S., and J. F. Pribnow: Studies on the radiosensitive phase of the primary antibody response. In: Proc. 3rd International Congress Radiation Research, Cortina d’Ampezzo 1966, p. 202.Google Scholar
- Simic, M. M., and M. Z. Petrovic: Effects of localized spleen irradiation on the primary immune response in rats: A histologic and serologic study. This Symposium.Google Scholar