Lymphoid Regeneration Following x-Ray Treatment and the Susceptibility to the Induction of Immunological Tolerance

  • D. Nachtigal


One of the main incentives for the study of the lymphoid system is its acknowledged role in the various manifestations of the immune response. The observations of Fishman (1961) suggest that antibody formation, at least, may depend on more than one cell type and that the lymphoid cells form antibody in response to instruction by macrophages. It would be tempting, therefore, to elucidate the possible function of these two cell series in other known immunological phenomena. The study reported here is an attempt to make some deductions along these lines with respect to the cellular basis of immunological tolerance.


Human Serum Albumin Antibody Formation Radiation Injury Tolerance Induction Immune Recovery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Donaldson, D. M., S. Marcus, K. K. Gyi, and E. M. Perkins: The influence of immunization and total body x-irradiation on the intracellular digestion by peritoneal phagocytes. J. Immunol. 76, 192–199 (1956).PubMedGoogle Scholar
  2. Fishman, M.: Antibody formation in vitro. J. exp. Med. 114, 837–854 (1961).PubMedCrossRefGoogle Scholar
  3. Gallily, R., and M. Feldman: The role of macrophages in the induction of antibody in x-irradiated animals. Immunology (in press). Also: this Sympsoium.Google Scholar
  4. Gordon, L. E., D. B. Cooper, and C. P. Miller: Clearance of bacteria from the blood of irradiated rabbits. Proc. Soc. exp. Biol. (N.Y.) 89, 577–579 (1955).Google Scholar
  5. Karthigasu, K., P. C. Reade, and C. R. Jenkin: The functional development of the reticuloendothelial system. III. The bactericidal capacity of fixed macrophages of fetal and neonatal diidis and rats. Immunology 9, 67–74 (1965).PubMedGoogle Scholar
  6. Keuning, F. J., and W. H. Bos: Regeneration patterns of lymphoid follicles in the rabbit spleen after sublethal x-irradiation. This Symposium.Google Scholar
  7. Nachtigal, D., and M. Feldman: Immunological unresponsiveness to protein antigens in rabbits exposed to x-irradiation or 6-mercaptopurine treatment. Immunology 6, 356–368 (1963).PubMedGoogle Scholar
  8. Nelson, E. L., and J. R. Becker: The effect of whole body x-irradiation on the bactericidal activity of phagocytic cells. I. Survival of Pseudomonas aeruginosa within phagocytes from peritoneal exudates of mice. J. infect. Dis. 104, 13–19 (1959 a).PubMedCrossRefGoogle Scholar
  9. Nelson, E. L., and J. R. BeckerThe effect of whole body x-irradiation on the bactericidal activity of phagocytic cells. II. Survival of Pseudomonas aeruginosa within liver and spleen of mice. J. infect. Dis. 104, 20–23 (1959 b).PubMedCrossRefGoogle Scholar
  10. Nossal, G. J. v., G. L. Ada, and C. M. Austin: Antigens in immunity. X. Induction of immunologic tolerance to Salmonella adelaide flagellins. J. Immunol. 95, 665–671 (1965).PubMedGoogle Scholar
  11. Silverman, S., and J. F. Pribnow: Studies on the radiosensitive phase of the primary antibody response. In: Proc. 3rd International Congress Radiation Research, Cortina d’Ampezzo 1966, p. 202.Google Scholar
  12. Simic, M. M., and M. Z. Petrovic: Effects of localized spleen irradiation on the primary immune response in rats: A histologic and serologic study. This Symposium.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • D. Nachtigal
    • 1
  1. 1.Section of Cell BiologyThe Weizmann Institute of ScienceRehovothIsrael

Personalised recommendations