Skip to main content
SpringerLink
Log in

Experimentation with Other Substances

  • Chapter
Experimental Studies on Guinea Pig’s Eczema

  • 34 Accesses

Abstract

In 1935, Landsteiner and Jacobs sensitized guinea pigs by repeated injections of small doses of PNDMA. The tests to control the sensitization were made by an intra-dermal injection. These authors also report (without giving details) that sensitization could be obtained with PNDMA “by rubbing guinea pigs with vaseline containing 5% of the compound”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature

  • Berger, W., u. F. J. Lang: Ein histopathologischer Beitrag zur Histaminhypothese der allergischen Reaktion. Z. Hyg. Infekt.-Kr. 113, 206–238 (1932).

    Article  Google Scholar 

  • Brun, R.: Contribution ä l’analvse des Chromates du ciment. Helv. chim. Acta 46, 2933–2939 (1963).

    Article  CAS  Google Scholar 

  • Brun, R.: Contribution á l’étude des Chromates du ciment. Nouvelle technique pour Ie test épi-cutané au ciment. Dermatologica (Basel) 129, 79–88 (1964).

    Article  Google Scholar 

  • Burgkhardt, W.: Die Rolle der Alkalischädigung der Haut bei experimenteller Sensibilisierung gegen Nickel. Arch. Derm. Syph. (Berl.) 173, 262–266 (1935).

    Article  Google Scholar 

  • Calnan, C. D.: Nickel sensitivity in women. Int. Arch. Allergy 11, 73–80 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Chase, M. W.: Experimental sensitization with particular reference to picryl chloride. Int. Arch. Allergy 5, 163–191 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Coca, A., Stewart, S. G., et P. E. Cormia: personal communication. J. Allergy 5, 575–582 (1934).

    Article  Google Scholar 

  • Cordonnier, V.: Etudes histo-chimiques de l’intolérance cutanée dans l’eczéma expérimental. Arch, beiges Derm. 5, 321 (1949).

    Google Scholar 

  • Dobkevitch, S., and R. L. Baer: Allergic eczematous dermatitis due to dyes in nylon stockings. Cross-sensitization to paraphenylendiamine (Preliminary report). J. invest. Derm. 8, 419–420 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Dobkevitch, S., and R. L. Baer: Eczematous cross-hypersensitivity to azodyes in nylon stockings and to paraphenylendiamine. J. invest. Derm. 9, 203–211 (1947).

    PubMed  CAS  Google Scholar 

  • Duesberg, J. P.: La dermite allergique du cobaye; son inhibition par la cortisone et le Phénergan. Arch, beiges Derm. 7, 274–283 (1951).

    Google Scholar 

  • Duesberg, J. P.: Histopathologic de la dermite allergique du cobaye, p. 70–73. In: Charpy, J. (Ed.): Le mécanisme physio-pathologique de l’eczéma. Paris: Masson 1954.

    Google Scholar 

  • Epstein, S.: Contact dermatitis due to nickel and Chromate. Observations on dermal delayed (tuberculin-type) sensitivity. Arch. Derm. (Chic.) 73, 236–255 (1956).

    Article  CAS  Google Scholar 

  • Epstein, S.: Contact dermatitis from Neomycin due to dermal delayed (tuberculin-type) sensitivity. Report of 10 cases. Dermatologica (Basel) 113, 191–201 (1956).

    Article  CAS  Google Scholar 

  • Epstein, S.: Dermal contact dermatitis. Sensitivity to Rivanol and gentian violet. Dermatologica (Basel) 117, 287–296 (1958).

    Article  CAS  Google Scholar 

  • Epstein, S.: Dermal contact dermatitis from Neomycin. Ann. Allergy 16, 268–280 (1958).

    PubMed  CAS  Google Scholar 

  • Epstein, W. L., and A. M. Kligman: The interference phenomenon in allergic contact dermatitis. J. invest. Derm. 31, 103–108 (1958).

    PubMed  CAS  Google Scholar 

  • Da Fonseca, A.: Dermatoses pelo cromio. Contribuicao para o estudo etiopatogenico das dermites de cause externa. Porto: Imprensa Portuguesa 1963.

    Google Scholar 

  • Graul, E. H., u. K. W. Kalkoff: Experimentelle Studien über den Vorgang der epidermalen Sensibillsierung. Arch. Derm. Syph. (Berl.) 187, 417–430 (1948/49).

    Article  Google Scholar 

  • Hunziker, N.: De l’eczéma experimental. Sème comm. A propos de l’hypersensibilité au bichromate de potassium chez le cobaye. Dermatologica (Basel) 121, 93–100 (1960).

    Article  CAS  Google Scholar 

  • Hunziker, N.: De l’eczéma expérimental. 9ème comm. Quelques expériences concernant la sensibilisation du cobaye au nickel. Dermatologica (Basel) 121, 307–312 (1960).

    Article  CAS  Google Scholar 

  • Hunziker, N.: Sensibilisation du cobaye ä la para-nitrosodimethylaniline (P-NDMA). A propos de l’acanthose eczémateuse. Dermatologica (Basel) 125, 117–120 (1962).

    Article  CAS  Google Scholar 

  • Hunziker, N.: De l’eczéma expérimental. 20e comm. Réactions du cobaye sensibilisé ä Tanhydride citraconique. Dermatologica (Basel) 129, 89–100 (1964).

    Article  CAS  Google Scholar 

  • Hunziker, N., E. Bujard u. W. Jadassohn: Bemerkungen zum experimentellen Kontaktekzem des Meerschweinchens. 19. Mitt. Hautarzt 15, 104–108 (1964).

    CAS  Google Scholar 

  • Hunziker, N., E. Bujard u. W. Jadassohn: Bemerkungen zum experimentellen Kontaktekzem des Meerschweinchens. 24. Mitt. Sensibilisierung des Meerschweinchens auf Propionsäureanhydrid (PA). Arch. klin. exp. Derm. 222, 527–532 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Hunziker, N., et E. Musso: Quelques remarques sur Teczéma professionnel au nickel. Dermatologica (Basel) 119, 40–45 (1959).

    Article  CAS  Google Scholar 

  • Jacobs, J. L.: Immediate generalized skin reactions in hypersensitive guinea pigs. Proc. Soc. exp. Biol. (N.Y.) 43, 641–643 (1940).

    CAS  Google Scholar 

  • Jacobs, J. L., T. S. Golden, and J. J. Kelley: Immediate reactions to anhydride, of wheal-and-erythema type. Proc. Soc. exp. Biol. (N.Y.) 43, 74–77 (1940).

    CAS  Google Scholar 

  • Jadassohn, W.: Eosinophile und urticarielle Quaddel. Arch. Derm. Syph. (Berl.) 166, 458–462 (1932).

    Article  Google Scholar 

  • Jadassohn, W., F. Schaaf: Über die Häufigkeit des Vorkommens von Nickelekzem. Arch. Derm. Syph. (Berl.) 157, 572–577 (1928/29).

    Article  Google Scholar 

  • Kern, R. A.: Asthma and allergic rhinitis due to sensitization to phthalic anhydride. J. Allergy 10, 164–165 (1938/39).

    Article  Google Scholar 

  • Landsteiner, K., and J. Jacobs: Studies on the sensitization of animals with simple chemical compounds. J. exp. Med. 61, 643–656 (1935).

    Article  PubMed  CAS  Google Scholar 

  • Landsteiner, K., A. Rostenberg, and M. B. Sulzberger: Individual differences in susceptibility to eczematous sensitization with simple chemical substances. J. invest. Derm. 2, 25–29 (1939).

    Article  CAS  Google Scholar 

  • Macher, E., u. W. Sennlaub: Über die Sensibilisierbarkeit von Meerschweinchen durch Applikation von Dinitrochlorbenzol in Lymphknoten oder Milz. Dermatologica (Basel) 126, 207–222 (1963).

    Article  CAS  Google Scholar 

  • Maggiora, A., E. Bujard, and W. Jadassohn: Different behavior of the epidermis of the flank and the nipple of the guinea pig after a 1600 R dose of X-rays. Dermatologica (Basel) 130, 306–311 (1965).

    Article  CAS  Google Scholar 

  • Mayer, R. L.: Die Überempfindlichkeit gegen Körper von Chinonstruktur. Arch. Derm. Syph. (Berl.) 156, 331–354 (1928).

    Article  Google Scholar 

  • Mayer, R. L.: Asthma und Ekzem bei den Pelzarbeiten (Ursolasthma, Ursolekzem). Arch. Derm. Syph. (Berl.) 158, 734–758 (1929).

    Article  Google Scholar 

  • Mayer, R. L.: Die Ursolidiosynkrasie des Meerschweinchens. Arch. Derm. Syph. (Berl.) 163, 223–244 (1931).

    Article  Google Scholar 

  • Mayer, R. L., u. Don Jaconia: Zur Frage der Chromüberempfindlichkeit. Allergie u. Asthma 4, 275–279 (1958).

    CAS  Google Scholar 

  • Mayer, R. L., u. M. B. Sulzberger: Zur Frage der jahreszeitlichen Schwankungen der Krankheiten. Der Einfluß der Kost auf experimentelle Sensibilisierungen. Arch. Derm. Syph. (Berl.) 163, 245–262 (1931).

    Article  Google Scholar 

  • Morris, G. E.: Chrome dermatitis. A study of the chemistry of shoe leather with particular reference to basic chromic sulfate. Arch. Derm. (Chic.) 78, 612–618 (1958).

    Article  CAS  Google Scholar 

  • Musso, E., et R. Brun: Essai d’un traitement désensibilisant chez des cobayes sensibilisés au blanc d’oeuf. Acta allerg. (Kbh.) 17, 105–111 (1962).

    CAS  Google Scholar 

  • Musso, E., N. Hunziker et A. Maggiora: Quelques remarques au sujet d’une enquête sur Teczéma au ciment en Europe. Acta allerg. (Kbh.) 27, 293–299 (1962).

    Google Scholar 

  • Nilzen, a., and K. Wikström: The influence of lauryl sulfate on the sensitization of guineapigs to chrome and nickel. Acta derm.-venereol. (Kbh.) 35, 292–299 (1955).

    CAS  Google Scholar 

  • Schwarz-Speck, M., u. H. Keil: Experimentelles Chrom-III-Ekzem. Dermatologica (Basel) 130, 373–384 (1965).

    Article  CAS  Google Scholar 

  • Soltermann, W.: Toxic epidermal necrolysis (Lyell.). Syndrom oder besonders schwere Verlaufsform einer Allergodermie ? Dermatologica (Basel) 118, 265–278 (1959).

    Article  CAS  Google Scholar 

  • Stewart, S. G., and F. E. Cormia: Experimental nickel dermatitis. J. Allergy 5,575–582 (1934).

    Article  Google Scholar 

  • Vandenberg, J. J., and W. L. Epstein: Experimental nickel contact sensitization in man. J. invest. Derm. 41, 413–418 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Vinson, L. J., and B. R. Choman: Percutaneous absorption and surface-active agents. J. Soc. Cosm. Chem. 11, 177–137 (1960).

    Google Scholar 

  • Walthard, B.: Die Erzeugung experimenteller Nickelidiosynkrasie bei Laboratoriumstieren. Schweiz, med. Wschr. 56, 603–604 (1926).

    Google Scholar 

  • Wikström, K.: Epidermal treatment of guinea pigs with potassium bichromate. Acta derm. venereol (Kbh.) 42, Suppl. 49, 1–59 (1962).

    Google Scholar 

  • Zak, F. G., M. J. Fellner, and A. J. Geller: Toxic epidermal necrolysis (Lyell). The scalded skin syndrome. Amer. J. Med. 37, 140–146 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Zeligman, I: Experimental contact dermatitis. II Contact dermatitis in guinea-pigs induced by paraphenylenediamine and related compounds. J. invest. Derm. 28, 121–135 (1957).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Prof. hon. E. Bujard (Medical School), University Clinic of Dermatology, Geneva, Switzerland

    Privat-docent Dr. Nicole Hunziker

Authors
  1. Privat-docent Dr. Nicole Hunziker
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Hunziker, N. (1969). Experimentation with Other Substances. In: Experimental Studies on Guinea Pig’s Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86672-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-86672-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86674-6

  • Online ISBN: 978-3-642-86672-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation