Forbidden Mutations

Ohno, Susumu

doi:10.1007/978-3-642-86659-3_6

Forbidden Mutations

Susumu Ohno²

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Abstract

Only the amino acid sequence of a polypeptide chain defines its function. A polypeptide chain having a certain amino acid sequence serves as a subunit of immunoglobulin, while another polypeptide chain having a different amino acid sequence functions as a subunit of an enzyme, such as lactate dehydrogenase. It then follows that a change in the amino acid sequence of a polypeptide chain can deprive that polypeptide chain from the performance of its assigned function.

Keywords

Natural Selection
Polypeptide Chain
Disulfide Bridge
Peptide Chain
Heme Group

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Department of Biology, City of Hope Medical Center, Duarte, Calif, USA
Dr. Susumu Ohno

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Dr. Susumu Ohno
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Ohno, S. (1970). Forbidden Mutations. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_6

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DOI: https://doi.org/10.1007/978-3-642-86659-3_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-86661-6
Online ISBN: 978-3-642-86659-3
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