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Mutation as a Change in the Base Sequence of a DNA Cistron

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Abstract

Due to an inherent complementality which exists between the two base pairs, adenine-thymine and guanine-cytosine, DNA is endowed with the unique property of being able to make an exact replica of itself before each cell division. Yet, if the mechanism of DNA replication were perfect and there was no room for mistakes, the creation of divergent living creatures from a common ancestor could not have happened.

Keywords

  • Polypeptide Chain
  • Nonsense Mutation
  • Base Substitution
  • Nonsense Codon
  • Ambiguous Code

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Fitch, W.M.: An improved method of testing for evolutional homology. T. Mol. Biol. 16 9–16(1966).

    CrossRef  CAS  Google Scholar 

  • Garen, A.: Sense and nonsense in the genetic code. Science 160, 149–159 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Kilmartin, J.V., Clegg, J.B.: Amino-acid replacements in horse hemoglobin. Nature 213, 269–271 (1967).

    PubMed  CrossRef  CAS  Google Scholar 

  • Terzaghi, E., Okada, Y., Streisinger, G., Emrich, J., Inouye, M., Tsugita, A.: Change of a sequence of amino acids in phage T4 lysozyme by acridine induced mutations. Proc. Natl. Acad. Sci. US 56, 500–507 (1966).

    CrossRef  CAS  Google Scholar 

  • Whitfield, H.J., Martin, R.G., Ames, B.N.: Classification of aminotransferase (C gene) mutants in the histidine operon. J. Mol. Biol. 21, 335–355 (1966).

    PubMed  CrossRef  CAS  Google Scholar 

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© 1970 Springer Science+Business Media New York

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Ohno, S. (1970). Mutation as a Change in the Base Sequence of a DNA Cistron. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-86659-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86661-6

  • Online ISBN: 978-3-642-86659-3

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