Zusammenfassung
Die Vorstellung, daß die energetischen. Bedürfnisse des Organismus ganz überwiegend durch die Mobilisation und Verbrennung von Kohlenhydraten gedeckt werden (Gemmill, 1942), läßt sich heute nicht mehr aufrecht erhalten. Abgesehen davon, daß die Glykogenvorräte gar nicht ausreichen würden, um bei längerem Nahrungsentzug die calorische Homöostase des Organismus aufrecht zu erhalten, sprechen auch Messungen des respiratorischen Quotienten im Hungerzustand oder bei Muskelarbeit gegen eine bevorzugte Utilisation von Kohlenhydraten (Issekutz, 1964).
Mit dankenswerter Unterstützung durch die Deutsche Forschungsgemeinschaft (We 272).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Ahlquist, R. P.: A study of the adrenotropic receptors. Amer. J. Physiol. 153, 586 (1948).
Ariens, E. J., J. M. van Rossum, and A. M. Simonis: A theoretical basis of molecular pharmacology. Part I: Interaction of one or two compounds with one receptor system. Arzneimittel-Forsch. 6, 282 (1956).
Astwood, E. B., R. J. Barrett, and H. Friesen: Two metabolically active peptides from porcine pituitary glands. Proc. nat. Acad. Sci. (Wash.) 47, 1525 (1961).
Aulich, A., K. Stock, and E. Westermann: Lipolytic effects of cyclic adenosine-3, 5′-monophosphate and its dibutyryl derivative, and their inhibition by α-and β-adrenolytics. Life Sci. (1967) Im Druck.
Barrett, R. J., H. Friesen, and E. B. Astwood: Characterization of pituitary and peptide hormones by electrophoresis in starch gel. J. biol. Chem. 237, 432 (1962).
Beaton, J. R., A. J. Szlavko, B. M. Box, and J. A. F. Stenevson: Biological effects of anorexogenic and fat-mobilizing substances from rat urine. Canad. J. Physiol. Pharmacol. 42, 657 (1964).
Belleau, B.: Conformational pertubation in relation to the regulation of enzyme and receptor behaviour. Advances in Drug Research, Vol. 2, p. 89. London: Academic Press 1965.
Bernsmeier, A., u. W. Rudolph: Myocardstoffwechsel. Verh. dtsch. Ges. Kreisl.-Forsch. 27, 59 (1961).
Bieck, P., K. Stock, and E. Westermann: Lipolytic action of serotonin in vitro. Life Sci. 5, 2157 (1966).
E. Westermann —— — Über die Bedeutung des Serotonins im Fettgewebe. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 256, 218 (1967).
Bing, R. J., A. Siegel, I. Ungar, and M. Gilbert: Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Amer. J. Med. 16, 504 (19
Birk, Y., and C. H. Li: Isolation and properties of a new, biologically active peptide from sheep pituitary glands. J. biol. Chem. 239, 1048 (1964).
Bizzi, A., A. Jori, E. Veneroni, and S. Garattini: Effect of 3,5-Dimethylpyrazole on blood free fatty acids and glucose. Life Sci. 3, 1371 (1964).
Black, J. W., A. F. Crowther, R. G. Shanks, L. H. Smith, and A. C. Dornhorst: A new adrenergic β-receptor antagonist. Lancet 1964, I, 1080.
Bloom, B. M., and I. M. Goldman: The nature of catecholamine-adenine mononucleotide interactions in adrenergic mechanisms. Advances in Drug Research, Vol. 3, p. 121. London: Academic Press 1966.
Brodie, B. B., R. P. Maickel, and D. N. Stern: Autonomic nervous system and adipose tissue. In: Handbook of Physiology, Section 5, Adipose Tissue, p. 583. Baltimore: Williams and Wilkins Co., 1965.
Burns, J. J., K. I. Colville, L. A. Lindsay, and R. A. Salvador: Blockade of some metabolic effects of catecholamines by N-isopropyl methoxamine (BW 61-43). J. Pharmacol. exp. Ther. 144, 163 (1964).
L. A. Lindsay, and R. A. Salvador —, and L. Lemberger: N-Tertiary butyl methoxamine, a specific antagonist of the metabolic actions of epinephrine. Fed. Proc. 24, 298 (1965).
Carlson, L. A., and L. Orö: The effect of nicotinic acid on the plasma free fatty acids. Demonstration of a metabolic type of sympathicolysis. Acta med. scand. 172, 641 (1962).
—, and J. Östman: Effect of salicylates on plasma free fatty acids in normal and diabetic subjects. Metabolism 10, 781 (1961).
Chalmers, T. M., G. L. S. Pawan, and A. Kekwick: Fat-mobilizing and ketogenic activity of urine extracts: relation to corticotrophin and growth hormone. Lancet 1960, II, 6.
Dole, V. P.: Effect of nucleic acid metabolites on lipolysis in adipose tissue. J. biol. Chem. 236, 3125 (1961).
Fain, J. N., V. P. Kovacev, and R. O. Scow: Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat. J. biol. Chem. 240, 3522 (1965).
Fassina, G.: Effects on lipidmobilisation of the Beta-adrenergic blocking drugs, propranolol and INPEA. J. Pharm. Pharmacol. 18, 399 (1966).
Friesen, H. J., M. Irie, and R. J. Barrett: An immunologic study of two metabolically active peptides from the anterior pituitary gland. J. exp. Med. 115, 513 (1962).
Gemmill, C. L.: Fuel for muscular exercise. Physiol. Rev. 22, 32 (1942).
Gerritsen, G. C., and W. E. Dulin: The effect of ö-methylpyrazole-3-carboxylic acid on carbohydrate and free fatty acid metabolism. J. Pharmacol. exp. Ther. 150, 491 (1965a).
— — Effect of a new hypoglycémie agent, 3,5-dimethylpyrazole, on carbohydrate and free fatty acid metabolism. Diabetes 14, 507 (1965b).
Gordon, R. S., and A. Cherkes: Unesterified fatty acids in human blood plasma. J. clin. Invest. 35, 206 (1956).
— — Production of unesterified fatty acids from isolated rat adipose tissue incubated in vitro. Proc. Soc. exp. Biol. (N.Y.) 97, 150 (1958).
Havel, R. J.: Autonomie nervous system and adipose tissue. In: Handbook of Physiology, Section 5, Adipose Tissue, p. 575. Baltimore: Williams and Wilkins 1965.
Horton, E. W.: Biological activities of pure prostaglandines. Experientia (Basel) 21, 113 (1965).
Hunter, A., and C. E. Downs: The inhibition of arginase by amino acids. J. biol. Chem. 157, 427 (1945).
Hynie, S., G. Krishna, and B. B. Brodie: Theophylline, a tool for the study of the interaction of thyroid and sympathetic systems in hormone-induced lipolysis. Fed. Proc. 24, 188 (1965).
Issekutz, B.: Effect of exercise on the metabolism of plasma free fatty acids. In: Fat as a tissue, pp. 228. New York: Mc Graw-Hill Book Co. 1964.
Jungas, R. L., and E. G. Ball: Studies on the metabolism of adipose tissue. XII. The effects of insulin and epinephrine on free fatty acid and glycerol production in the presence and absence of glucose. Biochemistry 2, 383 (1963).
Keul, J., E. Doll, H. Steim, U. Fleer und H. Reindell: Über den Stoffwechsel des menschlichen Herzens. III. Der oxydative Stoffwechsel des menschlichen Herzens unter verschiedenen Arbeitsbedingungen. Pflügers Arch. ges. Physiol. 282, 43 (1965).
Klainer, L. M., Y. M. Chi, S. L. Freidberg, T. W. Rall, and E. W. Sutherland: Adenyl cyclase. IV. The effect of neurohormones on the formation of adenosine-3′,5′-phosphate by preparations from brain and other tissues. J. biol. Chem. 237, 1239 (1962).
Pilkington, T. R. E., R. D. Lowe, B. F. Robinson, and E. Titterington: Effect of adrenergic blockade on glucose and fatty acid mobilization in man. Lancet 1962, II, 316.
Raben, M. S., R. Landolt, F. A. Smith, K. Hofmann, and H. Yajima: Adipokinetic activity of synthetic peptides related to corticotropin. Nature (Lond.) 189, 681 (1961).
Rizack, M. A.: An epinephrine-sensitive lipolytic activity in adipose tissue. J. biol. Chem. 236, 657 (1961).
— Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine-3,5′-phosphate. J. biol. Chem. 239, 392 (1964).
Rudman, D., S. J. Brown, and M. F. Malkin: Adipokinetic actions of adrenocorticotropin, thyroid-stimulating hormone, vasopressin, α-and β-melanoeyte-stimulating hormones, fraction H, epinephrine and norepinephrine in the rabbit, guinea pig, hamster, rat, pig and dog. Endocrinology 72, 527 (1963).
M. F. Malkin —, M. F. Malkin, S. J. Brown, L. A. Garcia, and L. L. Abell: Inactivation of adrenocorticotropin,α-and β-melanocyte-stimulating hormones, vasopressin and pituitary fraction H by adipose tissue. J. Lipid Res. 5, 38 (1964).
M. F. Malkin, M. F. Malkin, S. J. Brown, L. A. Garcia, and L. L. Abell —, F. Seidman, S. J. Brown, and R. L. Hirsch: Adipokinetic activity of porcine fraction H in the rabbit, guinea pig, rat and mouse. Endocrinology 70, 233 (1962).
Schotz, M. C., and I. H. Page: Effect of adrenergic blocking agents on the release of free fatty acids from rat adipose tissue. J. Lipid Res. 1, 466 (1960).
Schwabe, U., u. A. Hasselblatt: Abfall von Blutzucker und unveresterten Fettsäuren nach Isoxazolderivaten. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 251, 121 (1965).
— — Hemmung der Lipolyse im Fettgewebe durch 5-Methylisoxazol-3-carbonsäure. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 255, 76 (1966).
Steinberg, D.: The dynamics of FFA mobilization and utilization. In: Drugs Affecting Lipid Metabolism. Basel: Karger 1966 (Im Druck).
—, E. Shafrir, and M. Vaughan: Direct effect of glucagon on release of unesterified fatty acids (UFA) from adipose tissue. Clin. Res. 7, 220 (1959).
M. Vaughan —, M. Vaughan, P. J. Nestel, and S. Bergström: Effects of prostaglandin E opposing those of catecholamines on blood pressure and on triglyceride breakdown in adipose tissue. Biochem. Pharmacol. 12, 764 (1963).
Stock, K., and E. Westermann: Concentration of norepinephrine. serotonin and histamine, and of amine-metabolizing enzymes in mammalian adipose tissue. J. Lipid Res. 4, 297 (1963).
— — Effect of α-methyl-dopa and α-methyl-m-tyrosine on the mobilization of free fatty acids. Experientia (Basel) 20, 495 (1964).
— — Quantitative estimation and tissue distribution of Kö 592, l-(3-methylphenoxy)-3-isopropyl-aminopropanol (2)-hydrochloride, a new β-receptor blocking agent. Biochem. Pharmacol. 14, 227 (1965a).
— — Über die Bedeutung des Noradrenalingehaltes im Fettgewebe für die Mobilisierung unveresterter Fettsäuren. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 251, 465 (1965b).
— — Über die lipolytische Wirkung von natürlichem und synthetischem adrenocorticotropen Hormon (ACTH). Naunyn-Schmiedebergs Arch. exp, Path. Pharmak. 251, 488 (1965c).
— — Über den Mechanismus der lipolytischen Wirkung des Physostigmins. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 252, 433 (1966a).
— — Hemmung der Lipolyse durch α-und β-Sympathicolytica, Nicotinsäure und Prostaglandin E1Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 254, 334 (1966b).
— — Competitive and non-competitive inhibition of lipolysis by α-and β-adrenergic blocking agents, methoxamine derivates and prostaglandin E1. Life Sci. 5, 1667 (1966c).
Strand, O., M. Vaughan, and D. Steinberg: Rat adipose tissue lipases: hormone sensitive lipase activity against triglycerides compared with activity against lower glycerides. J. Lipid Res. 5, 554 (1964).
Sutherland, E. W., and T. W. Rall: The relation of adenosine-3′,5′-phosphate and phosphorylase to the action of catechol amines and other hormones. Pharmacol. Rev. 12, 265 (1960).
Vaughan, M.: Effect of hormones on phosphorylase activity in rat adipose tissue. J. biol. Chem. 235, 3049 (1960).
—, and J. Barchas: Effects of melatonin and related compounds on the release of glycerol from rat adipose tissue in vitro. J. Pharmacol. exp. Ther. 152, 298 (1966).
—, J. E. Berger, and D. Steinberg: Hormone sensitive lipase activities in adipose tissue. J. biol. Chem. 239, 401 (1964).
J. E. Berger, and D. Steinberg —, and D. Steinberg: Glyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulation. In Handbook of Physiology, Section 5, Adipose Tissue, p. 239. Baltimore: Williams and Wilkins 1965.
Wenke, M. E., E. Mühlbachovà, and S. Hynie: Effects of some sympathicotropic agents on the lipid metabolism. Arch. int. Pharmacodyn. CXXXVI, 104 (1962).
Westermann, E.: Cumulative effects of reserpine on the pituitary-adrenocortical and sympathetic nervous system. In Drugs and Enzymes, pp. 381–392. Oxford: Pergamon Press 1965.
— Sympathicus und Fettstoffwechsel. Acta neuroveg. (Wien) XXX, H. 1-4 (1967).
— Die Lipolyse und ihre pharmakologische Beeinflußbarkeit. Fette in der Medizin 7, 8 (1966).
— Drugs affecting the mobilization of free fatty acids. In Pathophysiological and clinical aspects of lipid metabolism, p. 38–48. Stuttgart: Georg Thieme 1966.
— Stimulierung der Lipolyse durch Hypophysenhormone. Fette in der Medizin (1967) (Im Druck).
—, P. Bieck und K. Stock: Ausschüttung lipolytisch wirksamer Hypophysenhormone durch Stimulierung von „Muscarin-Reeeptoren“ im Gehirn. Naunyn-Sehmiedebergs Arch. exp. Path. Pharmak. 255, 93 (1966).
K. Stock —, u. K. Stock: Wirkung von α-Methyl-Dopa und α-Methyl-m-Tyrosin auf den Fettstoffwechsel der Ratte. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 299 (1964).
K. Stock, u. K. Stock — — Über die Wirkung von α-Sympathicolytica auf die Lipolyse. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 250, 290 (1965).
K. Stock, u. K. Stock — — und P. Bieck: False transmitter substances in mammalian adipose tissue. Progr. biochem. Pharmacol., Vol. 3, pp. 233–247. Basel-New York: Karger 1967.
White, J. E., and F. L. Engel: A lipolytic action of epinephrine and norepinephrine on rat adipose tissue in vitro. Proc. Soc. exp. Biol. (N.Y.) 99, 375 (1958).
— — Lipolytic action of corticotropin on rat adipose tissue in vitro. J. Clin. Invest. 37, 1556 (1958); Übersicht bei
Engel, F. L., and H. E. Lebovitz: Peptide Hormones. Some new developments and their clinical implications. Amer. J. Med. 35, 721 (1963).
Williamson, J. R.: Adipose tissue. Morphological changes associated with lipid metabolism. J. Cell. Biol. 20, 57 (1964).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Westermann, E. (1967). Mechanismus und pharmakologische Beeinflussung der endokrinen Lipolyse. In: Klein, E. (eds) Die Pathogenese des Diabetes Mellitus. Symposion der Deutschen Gesellschaft für Endokrinologie, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86329-5_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-86329-5_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-03996-9
Online ISBN: 978-3-642-86329-5
eBook Packages: Springer Book Archive