Effects of Adenyl Cyclase-Stimulating Factors of Vibrio Cholerae on Antibody Formation
Immune adjuvants are those substances that are capable of enhancing an immune response. A wide variety of adjuvants has been and is currently in use, ranging in composition from simple inorganic materials (Warren et al., 1969) through complex macromolecules such as the polynucleotides (Braun and Nakano, 1967) and including the heterologous chemical structures of myobacteria and bacteria (Freund et al., 1948; Munoz, 1964). The mechanisms by which adjuvants exert their effects on the cells of the immune system are at best poorly understood. Furthermore, it is unlikely, and indeed unnecessary, that all adjuvant materials possess a common mode of action. The immune response is a complex reaction involving interactions between cells and immunogens, cells and soluble mediators (Mackler, 1971) and among various cell types themselves (Miller and Mitchell, 1968). Accompanying these interactions are biochemical events within lymphoid cells, some of which are related to the energy processes required to drive the cellular metabolism, and some of which are probably related to the reception and transmission of the antigenic signal itself. Adjuvants may act by influencing any or all of these interactions and chemical processes. By studying the effects of adjuvants possessing similar properties, we hope to learn something about their mode of action and thus obtain a more complete knowledge of the cellular interactions and biochemical events of the immune response.
KeywordsAdenyl Cyclase Adenyl Cyclase Activity Tritiated Thymidine Mouse Spleen Cell Spleen Cell Culture
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