Abstract
The antigen-induced secretion of the chemical mediators histamine and slow-reacting substance of anaphylaxis (SRS-A) has been detected in human lung tissue from asthmatic patients (Brocklehurst, 1960). These same chemical mediators are also released from human lung tissue obtained from normal individuals after passive sensitization with sera from allergic patients and challenge with specific antigen (Sheard et al., 1967; Parish, 1967). The antigen-antibody initiated secretory mechanism is modulated by a variety of hormones, which affect the intracellular levels of cyclic nucleotides (Orange et al., 1971a; Kaliner et al., 1972; Tauber et al., submitted for publication). These findings suggest that the subpopulation of target cells involved in the immunologic release of chemical mediators have specific receptors for alpha and beta adrenergic, cholinergic, and prostaglandin hormones as well as for IgE antibody. Although the hormones noted above can themselves stimulate secretion in some tissues, in the reaction to be considered, they modulate the secretory process stimulated by antigen-antibody interaction, instead.
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References
Austen, K. F., and Becker, E. L., eds. Biochemistry of the Acute Allergic Reactions. Oxford, England: Blackwell Scientific (1968).
Austen, K. F., and Becker, E. L., eds. Biochemistry of the Acute Allergic Reactions, 2nd Symposium. Oxford, England: Blackwell Scientific (1971).
Bourne, H. R., Lichtenstein, L. M., and Melmon, K. L. “Pharmacologic Control of Allergic Histamine Release in Vitro: Evidence for an Inhibitory Role of 3′,5′-adenosine Monophosphate in Human Leukocytes,” J. Immunol. 108:695–705 (1972).
Brocklehurst, W. E. “The Release of Histamine and Formation of a Slow-Reacting Substance (SRS-A) During Anaphylactic Shock,” J. Physiol. 151:416–435 (1960).
Ferrendelli, J. A., Steiner, A. L., McDougal, D. R., and Kipnis, D. M. “The Effect of Oxotremorine and Atropine on cGMP and cAMP Levels in Mouse Cerebral Cortex and Cerebellum” Biochem. Biophys Res. Commun. 41:1061–1067 (1970).
George, W. J., Poison, J. B., O’Toole, A. G., and Goldberg, N. D. “Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart After Prefusion with Acetylcholine,” Proc. Nat. Acad. Sci. (U.S.A.) 66:398–403 (1970).
Gilman, A. G. “A Protein Binding Assay for Adenosine 3′,5′-Cyclic Monophosphate,” Proc. Nat. Acad. Sci. (U.S.A.) 67:305–312 (1970).
Graham, H. T., Bowry, O. H., Wheelwright, B. F., Lenz, M. A. and Parish, H. H. Jr. “Distribution of Histamine Among Leukocytes and Platelets,” Blood J. Hematol. 29:467–481 (1955).
Ishizaka, T., Ishizaka, K., Orange, R. P., and Austen, K. F. “The Capacity of Human Immunoglobulin E to Mediate the Release of Histamine and Slow-Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung,” J. Immunol. 104:335–343 (1970a).
Ishizaka, K., Tomioka, H., and Ishizaka, T. “Mechanisms of Passive Sensitization. I. Presence of IgE and IgG Molecules on Human Leukocytes,” J. Immunol. 105:1459–1467 (1970b).
Kaliner, M. A., and Austen, K. F. “The Antigen Activated Biochemical Steps in the Release of Mediators from Human Lung,” Fed. Proc. (in press).
Kaliner, M. A., Orange, R. P., Koopman, W. J., Austen, K. F., and LaRaia, P. J. “Cyclic Adenosine 3′,5′-Monophosphate in Human Lung,” Biochem. Biophys. Acta 252:160–164 (1971).
Kaliner, M. A., Orange, R. P., and Austen, K. F. “Immunological Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. IV. Enhancement by Cholinergic and Alpha Adrenergic Stimulation,” J. Exp. Med. 136:556–567 (1972).
Karim, S. M. M., Sandier, M., and Williams, E. D. “Distribution of Prostaglandins in Human Tissues,” Brit. J. Pharmacol. Chemother. 31:340–344 (1967).
Kay, A. B., and Austen, K. F. “The IgE-Mediated Release of an Eosinophil Leukocyte Chemotactic Factor from Human Lung,” J. Immunol. 107:899–902 (1971).
Kuo, J., Lee, T., Reyes, P. L., Walton, K. G., Donnelly, T. E., Jr., and Greengard, P. “Cyclic Nucleotide-Dependent Protein Kinases. X. An Assay Method for the Measurement of Guanosine 3′,5′-Monophosphate in Various Biological Materials and a Study of Agents Regulating Its Levels in Heart and Brain,” J. Biol. Chem. 247:16–22 (1972).
Orange, R. P., and Austen, K. F. “Immunologic and Pharmacologic Receptor Control of the Release of Chemical Mediators from Human Lung.” In The Biologic Role of the Immunoglobulin E System, D. D. Dayton, ed. Washington, D.C.: U.S. Govt. Printing Office (in press).
Orange, R. P., Austen, W. G., and Austen, K. F. “Immunological Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. I. Modulation by Agents Influencing Cellular Levels of Cyclic 3′,5′-Adenosine Monophosphate,” J. Exp. Med. 134:136s–148s (1971a).
Orange, R. P., Kaliner, M. A., LaRaia, P. J., and Austen, K. F. “Immunological Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. II. Influence of Cellular Levels of Cyclic AMP,” Fed. Proc. 30:1725–1729 (1971b).
Orange, R. P., Kaliner, M. A., and Austen, K. F. “Immunological Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. III. Biochemical Control Mechanisms Involved in the Immunologic Release of the Chemical Mediators.” In Biochemistry of the Acute Allergic Reactions, 2nd Symposium, K. F. Austen and E. L. Becker, eds. Oxford, England: Blackwell Scientific, pp. 189-202 (1971c).
Parish, W. E. “Antigen Induced Release of Histamine and SRS-A from Human Lung Passively Sensitized with Reaginic Serum,” Nature (London) 215:738–739 (1967).
— — —. “Reaginic and Nonreaginic Antibody Reactions on Anaphylactic Participating Cells.” In Control Mechanisms in Reagin Mediated Hypersensitivity, L. Goodfriend and A. Sehon, eds. New York: Marcel Dekker, Inc. (in press).
Piper, P. J., and Vane, J. R. “Release of Additional Factors in Anaphylaxis and Their Antagonism by Antiinflammatory Drugs,” Nature (London) 223:29–35 (1969).
Piper, P. J., and Walker, J. L. “The Release of Spasmogenic Substances from Human Chopped Lung Tissue and Its Inhibition,” Brit. J. Pharmcol. (in press).
Riley, J. F., and West, G. B. “Presence of Histamine in Tissue Mast Cells,” J. Physiol. 120:528–537 (1953).
Robison, G. A., Butcher, R. W. and Sutherland, E. W. Cyclic AMP. New York: Academic Press, pp. 17–46 (1971).
Sheard, P., Killingback, P. G., and Blair, A. M. J. N. “Release of Histamine and Slow-Reacting Substance with Mast Cell Changes After Challenge of Human Lung Sensitized Passively with Reagin in Vitro,” Nature (London) 216:283–284 (1967).
Shore, P. A., Burkhalter, A., and Cohen, Jr., V. H. “A Method for the Fluorometric Assay of Histamine in Tissues,” J. Pharmacol. Exp. Ther. 127:182–186 (1959).
Sullivan, A. K., Grimley, P. M., and Metzger, H. “Electron Microscopic Localization of Immunoglobulin E on the Surface Membrane of Human Basophils,” J. Exp. Med. 134:1403–1416 (1971).
Tauber, A. I., Kaliner, M. A., Stechschulte, D. J., and Austen, K. F. “Prostaglandins and the Immunological Release of Chemical Mediators from Human Lung,” Symposium on Medical Aspects of Prostaglandins and Cyclic AMP, Univ. of Michigan, Ann Arbor (in press).
Tauber, A. I., Kaliner, M. A., Stechschulte, D. J., and Austen, K. F. “Immunological Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. V. Effects of Prostaglandins on Release of Histamine (submitted for publication).
Tomioka, H., and Ishizaka, K. “Mechanisms of Passive Sensitization. II. Presence of Receptors for IgE on Monkey Mast Cells,” J. Immunol. 107:971–978 (1971).
Wasserman, S. I., Goetzl, E. J., and Austen, K. F. (manuscript in preparation).
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Kaliner, M., Austen, K.F. (1974). Hormonal Control of the Immunologic Release of Histamine and Slow-Reacting Substance of Anaphylaxis from Human Lung. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_13
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DOI: https://doi.org/10.1007/978-3-642-86026-3_13
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