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Endocrinology of the Hypothalamo-Pituitary-Gonadal Axis

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Cryptorchidism

Abstract

The hypothalamo-pituitary-gonadal axis controls testicular function and male reproduction. It begins to function in the prenatal period and undergoes continual development until puberty.

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References

  1. Winter AJ, Eskay RL, Porter JC (1974) Concentration and distribution of TRH and LRH in the fetal brain. J Clin Endocrinol Metab 39:960–963

    Article  Google Scholar 

  2. Kaplan LS, Grumbach MM (1976) The ontogenesis of human foetal hormones. II. Luteinizing hormone (LH) and follicle stimulating hormone (FSH). Acta Endo crinol 81:808–829

    CAS  Google Scholar 

  3. Furukashi N, Suzuki M, Fukaya T, Kono H, Tachibana J, Shinkawa O (1980) Effects of synthetic LH-RH and TRH on pituitary function in anencephalic infants. Gynecol Obstet Invest 11:231–236

    Article  Google Scholar 

  4. Chin KY (1938) The endocrine glands of anencephalic foetuses. Chin Med J [Suppl 2] 63–90

    Google Scholar 

  5. Zondek LH, Zondek T (1965) Observations on the testis in anencephaly with special references to the Leydig cells. Biol Neonat 8:329–347

    Article  PubMed  CAS  Google Scholar 

  6. Beam JG (1968) Anencephaly and the development of the male genital tract. Acta Pediatr Acad Sci (Hung) 9:159–180

    Google Scholar 

  7. Baker GT, Scrimgeour BJ (1980) Development of the gonad in normal and anencephalic human fetuses. J ReprodFertil 60:193–199

    Article  PubMed  CAS  Google Scholar 

  8. Faiman Ch, Winter SDJ, Reyes IF (1981) Endocrinology of the fetal testis. In: Burger H, Kretser D de (eds), The testis. Raven Press, New York

    Google Scholar 

  9. Gulyas BJ, Tullner WW, Hodgen GD (1977) Fetal or maternal hypophysectomy in rhesus monkeys (Macaca mulatta): Effects on the development of the testes and other endocrine organs. Biol Reprod 17:650–660

    PubMed  CAS  Google Scholar 

  10. Forest GM, Saez MJ, Bertrand J (1973) Assessment of gonadal function in children. Pediatrician 2:102–128

    Google Scholar 

  11. Tapainen J, Koivisto M, Vihko R, Huhtaniemi I (1981) Enhanced activity of the pituitary-gonadal axis in premature human infants. J Clin Endocrinol Metab 52:235–238

    Article  Google Scholar 

  12. Job JC, Chaussain JL, Garnier PE (1977) The use of luteinizing hormone-releasing hormone in pediatric patients. Hormone Res 8:171–187

    Article  PubMed  CAS  Google Scholar 

  13. Job JC, Pierson M (1981) Endocrinologie pédiatrique et croissance. Flammarion médecine-sciences, Paris

    Google Scholar 

  14. Waaler PE: Morphometric studies in undescended testes. In: Job Cl (ed), Cryptorchidism. Pediatric Adolescent Endocrinology. Karger, Basel

    Google Scholar 

  15. Hadžiselimovi F (1977) Cryptorchidism. Springer, Heidelberg Berlin New York

    Google Scholar 

  16. Tatò L, Masè R, Pinelli L, Pizzo P, Gaburro D (1979) Monorchidism. In: Job JC (ed) Cryptorchidism, diagnosis and treatment. Karger, Basel, pp 148–153

    Google Scholar 

  17. Swerdloff SR, Heber D (1981) Endocrine control of testicular function from birth to puberty. In: Burger H, Kretser D de (eds) The testis. Raven Press, New York

    Google Scholar 

  18. Eik-Nes KB (1970) The androgens of the testis. Marcel Dekker, New York

    Google Scholar 

  19. Wilson JD (1975) Metabolism of testicular androgens. In: Greep OR, Astwook BE (eds) Handbook of Physiology, sect 7/V. American Physiological Society, Washington D.C.

    Google Scholar 

  20. Ewing L, Brown BL (1977) Testicular steroidogenesis. In: Johnson DA, Gomes RW (eds) The testis, vol IV. Academic Press, New York

    Google Scholar 

  21. Tsang BK, Kinson AG (1980) Biogenesis of androgens and estrogens by the normal testis. In: Hafez ESE (ed) Descended and cryptorchid testis. Martinus Nijhoff, The Hague, Boston London

    Google Scholar 

  22. Molen JH van der, Rammerts GFF (1981) Testicular steroidogenesis. In: Burger H, Kretser D de (eds) The testis. Raven Press, New York

    Google Scholar 

  23. Yanaihava T, Troën P (1972) Studies of the human testis. I. Biosynthetic pathways for androgen formation in human testicular tissue in vitro. J Clin Endocrinol Metab 34:783–792

    Google Scholar 

  24. Forest GM (1971) Pattern of the response to HCG stimulation in prepubertal cryptorchid boys. In: Job Cl (ed) Cryptorchidism. Pediatric Adolescent Endocrinology. Karger, Basel

    Google Scholar 

  25. Berg AA, Lackgren G, Lundkrist K (1979) Androgen biosynthesis in cryptorchid and non-cryptorchid human testicular tissue. In: Bierich RJ, Giarola A (eds) Cryptorchidism. Academic Press, London New York Toronto Sidney San Francisco

    Google Scholar 

  26. Parvinen M, Hurme P, Niemi M (1970) Penetration of exogenous testosterone, pregnenolone, progesterone and cholesterol into the seminiferous tubulus of the rat. Endocrinology 87:1082–1084

    Article  PubMed  CAS  Google Scholar 

  27. Mainwaring WIP (1977) The mechanism of action of androgens. Springer, New York Heidelberg Berlin

    Book  Google Scholar 

  28. Liao S, Liang T, Fang S, Casteñeda E, Shao TC (1973) Steroid structure and androgenic activity. Specifíties involved in the receptor binding and nuclear retention of various androgens. J Biol Chem 248:6154–6162

    CAS  Google Scholar 

  29. Chamberlain J, Jagovinec C, Ofner P (1966) Catabolism of [4-14C] testosterone by subcellular fractions of human prostate. Biochem J 99:610–616

    PubMed  CAS  Google Scholar 

  30. Bruchovsky N, Wilson JD (1968) The conversion of testosterone to 5-androstol-17-/-a-3-one by rat prostate in vivo and in vitro. J Biol Chem 243:2012–2021

    PubMed  CAS  Google Scholar 

  31. Moore RJ, Wilson JD (1972) Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4-3-ketosteroid 5-oxidoreductase in the nuclear membrane of rat ventral prostate. J Biol Chem 247:958–967

    PubMed  CAS  Google Scholar 

  32. Allison VF (1964) Ultrastructural changes in the seminal vesicle epithelium of the rat following castration and androgen stimulation. Anat Rec 148:254

    Google Scholar 

  33. Orlandini G (1964) Effects of castration on mitochondria structure in accessory glands of the mouse. Arch Ital Anat Embriolog 71:149

    Google Scholar 

  34. Brandes D (1974) Fine structure and cytochemistry of male accessory sex organs. In: Brandes D (ed) Male accessory sex organs. Academic Press, New York

    Google Scholar 

  35. Nicander L (1965) An electron microscopic study of absorbing cells in the posterior caput epididymidis of rabbits. Z Zellforsch 66:829–847

    Article  PubMed  CAS  Google Scholar 

  36. Howard A, Pelc SR (1951) Nuclear incorporation of 17. p32 as demonstrated by autoradiography. Exp Cell Res 2:178–187

    Article  CAS  Google Scholar 

  37. Smith JA, Martin L (1973) Do cell cycle Proc Natl Acad Sci USA 70:1263

    Article  PubMed  CAS  Google Scholar 

  38. Ohno S (1977) Testosterone and cellular response. In: Blandau RJ, Bergsma D (eds) Morphogenesis and mal formation of the genital system. Liss, New York

    Google Scholar 

  39. Cunia RG, Lung B (1979) Development of male accessory gland. In: Hafez ESE (ed) Accessory glands of the male reproductive tract. Spring-Mills, E., Ann Arbor Science

    Google Scholar 

  40. Jost A (1946) Sur la différenciation sexuelle de l’embryon de lapin. Expériences de paraboise. CR Soc Biol 140:463–464

    Google Scholar 

  41. Donahue RP, Ito Y, Marfatia S, Hendren HW (1976) The production of Müllerian Inhibiting Substance by the fetal, neonatal and adult rat. Biol Reprod 15:329–334

    Article  Google Scholar 

  42. Siiteri KP, Wilson DJ (1974) Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38:113–122

    Article  PubMed  CAS  Google Scholar 

  43. Gloyna RE, Wilson DJ (1969) A comparative study of the conversion of testosterone to 17ßh-hydroxy-5-an-drostan-3-one (Dihydrotestosterone) by prostate and epididymis. J Clin Endocrinol Metab 29:970–977

    Article  PubMed  CAS  Google Scholar 

  44. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE (1974) Steroid 5-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 186:1213–1215

    Article  PubMed  CAS  Google Scholar 

  45. Peterson ER, Imperato-McGinley J, Gautier T, Sturla E (1977) Male Pseudohermaphroditism due to steroid 5-reductase deficiency. Am J Med 62:170–191

    Article  PubMed  CAS  Google Scholar 

  46. Imperato-McGinley J, Peterson ER, Gautier T, Sturla E (1979) Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5-reductase deficiency. N Engl J Med 300:1233–1237

    Article  PubMed  CAS  Google Scholar 

  47. Walsh CP, Madden DJ, Harrod JM, Goldstein LJ, MacDonald CP, Wilson DJ (1974) Familial incomplete male pseudohermaphroditism, Type 2. N Engl J Med 290:944–949

    Article  Google Scholar 

  48. Fisher KL, Kogut DM, Moore JR, Dobelsman U, Weitzman JJ, Isaacs HJr, Griffin EJ, Wilson DJ (1978) Clinical, endocrinological, and enzymatic characterization of two patients with 5-reductase deficiency: Evidence that a single enzyme is responsible for the 5-re-duction of cortisol and testosterone. J Clin Endocrinol Metab 47:653–664

    Article  PubMed  CAS  Google Scholar 

  49. Raifer J, Walsh PC (1977) Testicular descent. In: Blandau RJ, Bergsma D (eds) Birth Defects. Original Article Series, Vol 13, No 2. Morphogenesis and Malformation of the Genital System. Liss, New York

    Google Scholar 

  50. Dorrington JH, Fritz B, Armstrong DT (1976) Testicular estrogens; Synthesis by isolated Sertoli cells and regulation by follicles-stimulating hormone.Spielman CH,Lobl TJ,Kirton RT (eds)Regulatory mechanisms of male reproductive physiology.Excerpta Medica American Elsevier, Amsterdam Oxford New York

    Google Scholar 

  51. Franchimont P, Chori S, Hagelstein MT, Puraiswami S (1975) Existence of a follicle-stimulating hormone inhibiting factor,inhibinin bull seminal plasma. Nature (Lond) 257:402–404

    Article  CAS  Google Scholar 

  52. Setschell PB, Davis VR, Main JS (1977) Inhibin. In: Johnson DA, Gomes RW (eds) The testis, IV. Academic Press, New York San Francisco London

    Google Scholar 

  53. Suwa S, Maesaka H, Matsui I (1974) Serum LH and FSH responses to synthetic LH-RH in normal infants, children, and patients with Turner’s syndrome. Pediatrics 54:470–475

    PubMed  CAS  Google Scholar 

  54. Roth JC, Kelch RP, Kaplan SL, Grumbach MM (1972) FSH and LH response to luteinizing hormone-releasing factor in prepubertal and pubertal children, adult males and patients with hypogonadotropic and hypergonadotropic hypogonadism. J Clin Endocrinol Metab 35:926–930

    Article  PubMed  CAS  Google Scholar 

  55. Grumbach MM, Roth JC, Kaplan SL, Kelch RP (1974) Hypothalamic pituitary regulation of puberty in man. Evidence and concepts derived from clinical research. In: Grumbach MM, Grave DG, Mayer EF (eds) The control of the onset of puberty. Wiley, New York

    Google Scholar 

  56. Wollesen F, Swerdloff RS, Odell WD (1976) LH and FSH responses to luteinizing-releasing hormone in normal adult human males. Metabolism 25:845–863

    Article  PubMed  CAS  Google Scholar 

  57. Reiter EO, Root AW, Duckett GE (1976) The response of pituitary gonadotropes to a constant infusion of LHRH in normal prepubertal and pubertal children and in children with abnormalities of sexual development. J Clin Endocrinol Metab 43:400

    Article  PubMed  CAS  Google Scholar 

  58. Gendrei D, Job JCl, Roger M (1978) Reduced postnatal rise of testosterone in plasma of cryptorchid infants. Acta Endocrinol 89:372–378

    Google Scholar 

  59. Ingenbleck Y, Hoven FM van den, Deruelle M (1981) Differences in the retinol circulating complex between healthy male and female infants. Clinica Chimica Acta 114:219–224

    Article  Google Scholar 

  60. Hadžiselimovi F, Herzog B, Seguchi H (1975) Surgical correction of cryptorchidism at 2 years. Electron microscopic and morphometric investigations. J Pediat Surg 10:19–28

    Article  Google Scholar 

  61. Canlorbe P, Toublanc JE, Roger M, Job JCl (1974) Etude de la function endocrine dans 125 cas de cryptorchidies. Ann Med Interne 125:365

    CAS  Google Scholar 

  62. Lloyd III JW, Stecker JF, Rakestraw MG (1978) In vitro stimulation of adenosine 3’,5’-monophosphate in unilateral undescended testes of humans by follicle and luteinizing hormone. J Clin Endocrinol Metab 46:158–162

    Article  PubMed  CAS  Google Scholar 

  63. Engberg H (1949) Investigations of the endocrine function of the testicle in cryptorchidism. Proc R Soc Med 42:652–655

    PubMed  CAS  Google Scholar 

  64. Raboch J, Starka L (1972) Plasmatic testosterone in bilateral cryptorchids in adult age. Andrologie 4:107–112

    PubMed  CAS  Google Scholar 

  65. Lipschütz A, Ottow B (1920) Sur les consequences de la castration partielle. CR Soc Biol (Paris) 83:1340

    Google Scholar 

  66. Job C, Gamier PhE, Chaussain JL, Toublanc JE, Canlorbe P (1974) Effect of synthetic luteinizing hormone-releasing hormone on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. IV. Undescended testes. J Pediatr 84: 371–374

    Article  PubMed  CAS  Google Scholar 

  67. Jacobelli A, Agosto A, Vecci E, Simeoni A, Ferantelli M (1979) Studies on the pituitary-testicular axis in boys with cryptorchidism. In: Bierich JR, Giarolla A (eds) Cryptorchidism. Academic Press, London

    Google Scholar 

  68. Mazzi C, Riva LP, Morandi G, Mainini E, Scarsi G, Salaroli A (1979) A study of cryptorchid subjects. I. Evaluation of the hypophyseal-testicular axis in the prepubertal period. In: Bierich JR, Giarolla A (eds) Cryptorchidism. Eds.: Academic Press, London

    Google Scholar 

  69. Tatò L, Masé R, Rossignoli R, Pinelli L, Gaburro D (1979) Some semiological aspects of cryptorchidism in prepubertal boys. Testicular volume and gonadotropin responses to LH-RH. In: Bierich JR, Giarolla A (eds) Cryptorchidism. Academic Press, London

    Google Scholar 

  70. Vanelli N, Bernasconi R, Vipdis R, Giovannelli G (1981) Gonadotropine response to 3 hours LHRH infu sion in cryptorchid and normal children. Pediatr Res 15:88

    Article  Google Scholar 

  71. Cacciari E, Cicognani A, Pirazzoli P, Zappola F, Tassoni P, Bernardi F, Salardi S (1976) Hypophysogonadal function in the cryptorchid children. Difference between unilateral and bilateral cryptorchidism. Acta Endocrinol [Copenh] 83:182–189

    CAS  Google Scholar 

  72. Happ J (1981) Therapie mit Gonadotropin-Releasing-Hormon. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  73. Rehorek R (1982) Die Beziehung der Sertoli-Zelle zu der hypothalamo-hypophyso-gonadalen Achse bei kryptorchen präpubertalen Knaben. Inaugural-Dissertation der Medizinischen Universität Basel

    Google Scholar 

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  1. F. Hadžiselimović
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© 1983 Springer-Verlag Berlin · Heidelberg

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Hadžiselimović, F. (1983). Endocrinology of the Hypothalamo-Pituitary-Gonadal Axis. In: Cryptorchidism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86020-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-86020-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86022-5

  • Online ISBN: 978-3-642-86020-1

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