Abstract
The relationship of chromocenters of interphase nuclei to the hetero-chromatin of metaphase chromosomes is well studied for the sex chromosomes of man and mammals (Ohno et al., 1959; Schmid, 1967; Tiepolo et al., 1967; Zakharov and Egolina, 1938). One of the most important implications of this relationship is the inactive-X hypothesis expressed by Lyon (1961). Genetic inactivation and heterochromatinization can be assumed to be characteristic features of one of the X-chromosomes in the female. Asynchronous late replication of the DNA is a further remarkable phenomenon shown by the X-heterochromatin.
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References
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Gropp, A., Citoler, P. (1969). Patterns of Autosomal Heterochromatin. In: Benirschke, K. (eds) Comparative Mammalian Cytogenetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85943-4_17
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DOI: https://doi.org/10.1007/978-3-642-85943-4_17
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