Patterns of Autosomal Heterochromatin

  • A. Gropp
  • P. Citoler


The relationship of chromocenters of interphase nuclei to the hetero-chromatin of metaphase chromosomes is well studied for the sex chromosomes of man and mammals (Ohno et al., 1959; Schmid, 1967; Tiepolo et al., 1967; Zakharov and Egolina, 1938). One of the most important implications of this relationship is the inactive-X hypothesis expressed by Lyon (1961). Genetic inactivation and heterochromatinization can be assumed to be characteristic features of one of the X-chromosomes in the female. Asynchronous late replication of the DNA is a further remarkable phenomenon shown by the X-heterochromatin.


Metaphase Chromosome Interphase Nucleus Fibroblast Culture Labelling Pattern Male Fetus 
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Copyright information

© Springer-Verlag New York Inc. 1969

Authors and Affiliations

  • A. Gropp
    • 1
  • P. Citoler
    • 1
  1. 1.Abteilung für Cytopathologie und Cytogenetik des Pathologischen InstitutsUniversität BonnGermany

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