Oncogenes in Colorectal Cancer

  • N. James
  • K. Sikora


Carcinogenesis is a multistage process known to involve changes at the genetic level. Over the last decade it has become possible to identify precisely some of the genes involved in this process. These are called “oncogenes”. Intriguingly, similar DNA sequences are present in species as diverse as yeast, Drosophila and man. This high degree of conservation across vast reaches of evolutionary time would appear to indicate a role of fundamental importance in normal cellular function. Thus, it is not surprising that abnormalities affecting these genes have serious consequences. An “oncogene” can be defined as a gene whose changed expression or altered product is essential to the production or maintenance of the malignant state.


Colorectal Carcinoma Familial Adenomatous Polyposis Oncogene Product Familial Polyposis Coli Cellular Oncogene 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. James
    • 1
  • K. Sikora
    • 1
  1. 1.Department of Clinical OncologyRoyal Postgraduate Medical School, Hammersmith HospitalLondonUK

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