Carcinogenesis is a multistage process known to involve changes at the genetic level. Over the last decade it has become possible to identify precisely some of the genes involved in this process. These are called “oncogenes”. Intriguingly, similar DNA sequences are present in species as diverse as yeast, Drosophila and man. This high degree of conservation across vast reaches of evolutionary time would appear to indicate a role of fundamental importance in normal cellular function. Thus, it is not surprising that abnormalities affecting these genes have serious consequences. An “oncogene” can be defined as a gene whose changed expression or altered product is essential to the production or maintenance of the malignant state.
KeywordsColorectal Carcinoma Familial Adenomatous Polyposis Oncogene Product Familial Polyposis Coli Cellular Oncogene
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