Oncogenes in Colorectal Cancer

  • N. James
  • K. Sikora
Chapter

Abstract

Carcinogenesis is a multistage process known to involve changes at the genetic level. Over the last decade it has become possible to identify precisely some of the genes involved in this process. These are called “oncogenes”. Intriguingly, similar DNA sequences are present in species as diverse as yeast, Drosophila and man. This high degree of conservation across vast reaches of evolutionary time would appear to indicate a role of fundamental importance in normal cellular function. Thus, it is not surprising that abnormalities affecting these genes have serious consequences. An “oncogene” can be defined as a gene whose changed expression or altered product is essential to the production or maintenance of the malignant state.

Keywords

Lymphoma Tyrosine Adenocarcinoma Adenoma Glycine 

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References

  1. Bishop JM, Warmus H (1982) Functions and origins of retroviral transforming genes in RNA tumour viruses. In: Weiss RA, Teich N, Warmus H, Coffin J (eds) RNA tumor viruses: molecular biology of tumor viruses. Cold Spring Harbor, New York, pp 999–1108Google Scholar
  2. Bodmer WF, Bailey CJ, Bodmer J et al. (1987) Localisation of the gene for familial adenomatous polyposis and chromosome 5. Nature 328: 614–616PubMedCrossRefGoogle Scholar
  3. Brodeur GM, Seeger RC, Schwab M et al. (1985) Amplification of n-myc and untreated human neuroblastomas correlates with advanced disease state. Science 231: 1121–1124Google Scholar
  4. Der CJ, Cooper GM (1983) Altered gene products are associated with activation of cellular ras K genes in human lung and colon carcinomas. Cell 32: 201–208PubMedCrossRefGoogle Scholar
  5. Evan G, Hancock DC (1986) Studies on the interaction of the human c-myc protein with cell nuclei. Cell 43: 253–261CrossRefGoogle Scholar
  6. Gale RP, Cannani E (1985) The molecular biology of chronic myeloginous leukaemia. Br J Haematol 60: 395 –408Google Scholar
  7. Hamlyn PH, Rabbits TH (1983) Translocation joint c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma. Nature 304: 135–139PubMedCrossRefGoogle Scholar
  8. Sainsbury JRC, Farndon JR, Sherbert GV et al. (1985) Epidermal growth factor receptors and oestrogen receptors in human breast cancer. Lancet 1: 364–366PubMedCrossRefGoogle Scholar
  9. Sherr CJ, Rettenmeyer CW, Saccar et al. (1983) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF1. Cell 41: 665–667CrossRefGoogle Scholar
  10. Sikora K, Evan G, Stewart J, Watson J (1985) Detection of the c-myc oncogene product of testicular cancer. Br J Cancer 82: 171–176CrossRefGoogle Scholar
  11. Solomon E, Voss R, Hall V et al. (1987) Chromosome 5 allele loss in human colorectal carcinomas. Nature 328: 616–618PubMedCrossRefGoogle Scholar
  12. Spandidos DA, Kerr IB (1984) Elevated expression of the human ras oncogene family in pre-malignant and malignant tumours of the colorectum. Br J Cancer 49: 681–688PubMedCrossRefGoogle Scholar
  13. Stewart J, Evan G, Watson J, Sikora A (1986) Detection of the c-myc oncogene product in colonic polyps and carcinomas. Br J Cancer 53: 1–6PubMedCrossRefGoogle Scholar
  14. Venter DJ, Tuzi NL, Kumar S, Gullick WJ (1987) Over expression of the c-erbB2 oncoprotein in human breast carcinomas. Lancet 2: 69–72PubMedCrossRefGoogle Scholar
  15. Waterfield MD, Scrace GT, Whittle N et al. (1983) Platelet derived growth factor structurally related to the putative transforming protein p28 sis of Simian sarcoma virus. Nature 304: 35–39PubMedCrossRefGoogle Scholar
  16. Weinberg RA (1982) Fewer and fewer oncogenes. Cell 30: 3–4PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. James
    • 1
  • K. Sikora
    • 1
  1. 1.Department of Clinical OncologyRoyal Postgraduate Medical School, Hammersmith HospitalLondonUK

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