Abstract
In the treatment of epilepsy two or more drugs are often combined, and in such cases the possibility of drug interaction is present. Interaction between phenobarbitone (PB) and diphenylhydantoin (DPH) has been reported in several papers (Cucinell et al., 1965; Kristensen et al., 1969; Kutt et al., 1969; Morselli et al., 1971).
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References
Burns, J. J., Cucinell, S. A., Koster, R., Conney, H.: Application of drug metabolism to drug toxicity studies. Ann. N. Y. Acad. Sci. 123, 273 (1965).
Christiansen, J.: Assay of carbamazepine and metabolites in plasma by quantitative thin-layer chromatography. In: Methods of analysis of antiepileptic drugs. (Eds. J. W. A. Meijer, H. Meinardi, C. Gardner-Thorpe, E. van der Kleijn), ICS 286, 87. Amsterdam: Excerpta Medica, New York: American Elsevier Co., Inc. 1973.
Christiansen, J., Dam, M.: Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy. Acta neurol. scand. 49, 543 (1973).
Cucinell, S. A., Conney, A. H., Sansur, M., Burns, J. J.: Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydroxycoumarin and diphenylhydantoin. Clin. Pharmacol. Ther. 6, 420—429 (1965).
Harbison, R. D., Eling, T. E., Becker, B. A.: Effect of diphenylhydantoin on neonatal rat liver drug metabolising enzymes. Fed. Proc. 28, 676 (1969).
Kristensen, M., Mollholm Hansen, J., Skovsted, L.: Influence of phenobarbital on the half- life of diphenyl-hydantoin. Acta med. scand. 185, 347 (1969).
Kutt, H., Haynes, J., Verebely, K., McDowell, F.: The effects of phenobarbital on plasma diphenylhydantoin level and metabolism in man and in rat liver microsomes. Neurology (Minneap.) 19, 611 (1969).
Morselli, P. L., Rizzo, M., Garattini, S.: Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients. Ann. N. Y. Acad. Sci. 179, 88 (1971).
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Christiansen, J., Dam, M. (1975). Drug Interaction in Epileptic Patients. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_19
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DOI: https://doi.org/10.1007/978-3-642-85921-2_19
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