Aspects of Altered Gene Expression in Heart Failure and Myocardial Hypertrophy
The phenotype and the function of differentiated eukaryotic cells is determined by the functional condition of their proteins (ion channels, enzymes), the protein expression (transcriptional and post-transcriptional regulation), the protein biosynthesis (translation) and the underlying nucleotide sequence in the genetic code (possible mutation of the genome). Changes, which influence the functional properties and the structure of the cell, can occur at each of these levels.
KeywordsSarcoplasmic Reticulum Altered Gene Expression Myocardial Hypertrophy Contractile Apparatus Intracellular Calcium Homeostasis
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