Chemotherapeutic and Immunological Considerations on the Response of Choriocarcinomas

  • Min C. Li
Conference paper
Part of the UICC Monograph Series book series (UICC, volume 3)


Choriocarcinoma can originate either from the products of conception, or from the germinal cells of the gonads of either sex. Rarely, it may arise from embryonal rest cells in extra-gonadal sites such as the mediastinum, pineal body, lung, stomach, urinary bladder, and tissues in the retroperitoneal area. Although choriocarcinoma of different origins are similar in their histological appearance, in the production of chorionic gonadotropin and in their clinical behaviour and rapid dissemination, they respond differently to chemotherapeutic agents and they differ in their host-tumor relationships. The present report deals with the findings of investigations on these two topics.


Folic Acid Homograft Rejection Cheek Pouch Complete Tumor Regression Trophoblastic Tumor 
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  1. Brown, J. H., and Kennedy, B. J., Mithramycin in the treatment of disseminated testicular neoplasms. New Engl. J. Med. 272, 111–118 (1965).PubMedCrossRefGoogle Scholar
  2. Grace J. T., Jr. Discussion of the paper entitled “Induced immunity to cancer cell homografts in man”, by Southam, C. M., and Moore, A. E. Am. N. Y. Acid. Sci. 73, 651–653 (1958).Google Scholar
  3. Li, M. C., Hertz, R. and Bergenstal, D. M., Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists. New Engl. J. Med. 259, 66–74 (1958).PubMedCrossRefGoogle Scholar
  4. Li, M. C., Whitmore, W. F., Jr., Goldberg, R., and Grabstald, H., Effects of combined drug therapy on metastatic cancer of testis. J. Amer, med Ass. 174, 1291–1299).Google Scholar
  5. MacKenzie, A. R., Personal communication, speech given to the New York Cancer Society in December 1964.Google Scholar
  6. Mathe, G., Dausset, J., Herret, E., Amiel, J. L., Colombani, J., and Brule, G., Immunological studies in patients with placental choriocarcinoma. J. nat. Cancer Inst. 33, 193–208 (1964).PubMedGoogle Scholar
  7. Robinson, E., Shulman, J., Ben-Hur, N., Zuckerman, H., and Neuman, Z., Immunological studies and behavior of husband and foreign homografts in patients with chorioepithelioma. Lancet, 1963 I, 300 – 302.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • Min C. Li
    • 1
  1. 1.Nassau HospitalMineolaUSA

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