Chemotherapeutic and Immunological Considerations on the Response of Choriocarcinomas
Choriocarcinoma can originate either from the products of conception, or from the germinal cells of the gonads of either sex. Rarely, it may arise from embryonal rest cells in extra-gonadal sites such as the mediastinum, pineal body, lung, stomach, urinary bladder, and tissues in the retroperitoneal area. Although choriocarcinoma of different origins are similar in their histological appearance, in the production of chorionic gonadotropin and in their clinical behaviour and rapid dissemination, they respond differently to chemotherapeutic agents and they differ in their host-tumor relationships. The present report deals with the findings of investigations on these two topics.
KeywordsToxicity Depression Estrogen Diarrhea Methotrexate
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- Grace J. T., Jr. Discussion of the paper entitled “Induced immunity to cancer cell homografts in man”, by Southam, C. M., and Moore, A. E. Am. N. Y. Acid. Sci. 73, 651–653 (1958).Google Scholar
- Li, M. C., Whitmore, W. F., Jr., Goldberg, R., and Grabstald, H., Effects of combined drug therapy on metastatic cancer of testis. J. Amer, med Ass. 174, 1291–1299).Google Scholar
- MacKenzie, A. R., Personal communication, speech given to the New York Cancer Society in December 1964.Google Scholar