Skip to main content

Remissions Induced in Patients with Trophoblastic Tumors by 6-Diazo-5-Oxo-L-Norleucine (DON)

  • Conference paper
  • 34 Accesses

Part of the book series: UICC Monograph Series ((UICC,volume 3))

Abstract

Trophoblastic tumors associated with pregnancy comprise a fascinating spectrum of diseases. Several aspects of these tumors relate directly to major problems in cancer research and therapy.

The work reported in this article was supported in part by research grants CA-03215 and CA-05826 from the National Cancer Institute, Public Health Service, Department of Health, Education and Welfare.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Brewer, J. I., Smith, R. T., and Pratt, G. B., Choriocarcinoma. Absolute 5 year survival rates of 122 patients treated by hysterectomy. Amer. J. Obstet. Gynec. 85, 841–843 (1963).

    PubMed  CAS  Google Scholar 

  • Buchanan, J. M., Hartman, S. C., Herrmann, R. L., and Day, R. A.; Reactions involving the carbon-nitrogen bond: heterocyclic compounds. J. cell. comp. Physiol. 54, 139–160 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Clarke, D. A., Reilly, H. C., and Stock, C. C., Comparative study of 6-diazo-5-oxo-L-norleucine and O-diazoacetyl-L-serine on sarcoma 180. Proc. Amer. Ass. Cancer Res. 2, 100 (1956).

    Google Scholar 

  • Ellison, R. R., Karnofsky, D. A., Sternberg, S. S., Murphy, M. L., and Burchenal, J.H., Clinical trials of O-diazoacetyl-L-serine (azaserine) in neoplastic disease. Cancer (Philad.) 1, 801–814 (1954).

    Article  Google Scholar 

  • Hertz, R., Personal communication

    Google Scholar 

  • Hertz, R., Bergenstal, D. M., Lipsett, M. B., Price, E. G., and Hilbish, T. F., Chemotherapy of choriocarcinoma and related trophoblastic tumors in women. J. Amer. med. Ass. 168, 845–854 (1958).

    Article  CAS  Google Scholar 

  • Hertz, R., Lewis, J., Jr., and Lipsett, M. B., Five years’ experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynec. 82, 631–640 (1961).

    PubMed  CAS  Google Scholar 

  • Hertz, R., Lipsett, M. B., and Moy, R. H., Effect of vincaleukoblastine on metastatic choriocarcinoma and related trophoblastic tumors in women. Cancer Res. 20, 1050–1053 (1960).

    PubMed  CAS  Google Scholar 

  • Karnofsky, D. A., Drugs as teratogens in animals and man. Ann. Rev. Pharmacol. 5, 447–472 (1965).

    Article  CAS  Google Scholar 

  • Karnofsky, D. A., Myers, W.P.L., and Phillips, R., Treatment of the inoperable pulmonary cancer primary and metastatic. Amer. J. Surg. 89, 526–537 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Li, M. C., Hertz, R., and Spencer, D. B., Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc. Soc. exp. Biol. (N. Y.) 93, 361–366 (1956).

    Google Scholar 

  • Magill, G. B., Myers, W. P. L., Reilly, H. C., Putnam, R. C., Magill, J. W., Sykes, M. P., Escher, G. C., Karnofsky, D. A., and Burchenal, J. H., Pharmacological and initial therapeutic observations on 6-diazo-5-oxo-L-norleucine (DON) in human neoplastic disease. Cancer (Philad.) 10, 1138–1150 (1957).

    Article  CAS  Google Scholar 

  • Murphy, M. L., Teratogenic effects in rats of growth inhibiting chemicals, including studies on thalidomide. Clin. Proc. Child. Hosp. (Wash.) 18, 307–322 (1962).

    CAS  Google Scholar 

  • Myers, W. P. L., and Magill, G. B., Alterations in calcium metabolism in cancer patients treated with 6-diazo-5-oxo-L-norleucine. Proc. Soc. exp. Biol. (N.Y.) 93, 314–318 (1956).

    CAS  Google Scholar 

  • Ross, G. T., Stalbach, L. L., and Hertz, R., Actinomycin D in the treatment of methotrexate-resistant trophoblastic disease in women. Cancer Res. 22, 1015–1017 (1962).

    PubMed  CAS  Google Scholar 

  • Sung, H-C., Wu, P-C, and Ho, T-H., Treatment of choriocarcinoma and chorioadenoma destruens with 6-mercaptopurine and sugery. Acta Un. int. Cancr. 20, 493–502 (1964).

    PubMed  CAS  Google Scholar 

  • Thiele, R. A., and de Alvarez, R. R., Metastasizing benign trophoblastic tumors. Amer. J. Obstet. Gynec. 84, 1395–1406 (1962).

    PubMed  CAS  Google Scholar 

  • Thiersch, J. B., Therapeutic abortions with a folic acid antagonist 4-amino-pteroylglutamic acid (4-amino P. G. A.) administered by the oral route. Amer. J. Obstet. Gynec. 63, 1298–1304 (1952).

    PubMed  CAS  Google Scholar 

  • Thiersch, J. B., and Phillips, F. S., Effect of 4-amino-pteroylglutamic acid (aminopterin) in early pregnancy. Proc. Soc. exp. Biol. (N. Y.) 74, 204–208 (1950).

    CAS  Google Scholar 

  • Thiersch, J. B., and Phillips, F. S., Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 1–284 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1967 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Karnofsky, D.A., Golbey, R.B., Li, M.C. (1967). Remissions Induced in Patients with Trophoblastic Tumors by 6-Diazo-5-Oxo-L-Norleucine (DON). In: Holland, J.F., Hreshchyshyn, M.M. (eds) Choriocarcinoma. UICC Monograph Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85907-6_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85907-6_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85909-0

  • Online ISBN: 978-3-642-85907-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics