Abstract
At the time of the trial organization, the literature on the subject of calcium antagonists was still limited. Calcium antagonists were thought to be of benefit by virtue of their effects on cellular metabolism and on collateral circulation.
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References
Allen GS, Ahn HS, Preziosi TJ et al. (1983) Cerebral arterial spasm — a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:619–624
Altura BT, Altura BM (1981) Magnesium deficiency induces cerebral vasospasm. Stroke 12:118
Battye R (eds) (1984) Calcium antagonists; possible therapeutic uses in neurosurgery. Proceedings of 10–11 June, 1983 workshop held in Dorado Beach, Puerto Rico. Raven Health Care Communications, New York
Berger JR, Busto R, Ginsberg MD (1984) Verapamil: failure of metabolic amelioration following global forebrain ischemia in the rat. Stroke 15:1029–1032
Brandt L, Ljunggren B, Anderson KE (1983) Effects of topical application of a calcium antagonist (nifedipine) on feline cortical pial microvasculature under normal conditions and in focal ischemia. J Cereb Blood Flow Metab 3:44–50
Faden AI, Jacobs TP, Smith MT (1984) Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia. J Neurosurg 60:796–799
Gelmers HJ (1984) The effects of nimodipine on the clinical course of patients with acute ischemic stroke. Acta Neurol Scand 69:232–239
Gross CR, Kase CS, Mohr JP, Cunningham SC, Baker WE (1984) Stroke in south Alabama: incidence and diagnostic features. A population-based study. Stroke 15:249–254
Hass WK (1981) Beyond cerebral blood flow, metabolism, and ischemic thresholds: an examination of the role of calcium in the initiation of cerebral infarction. In: Lechner H, Reivich M, Oht EO, Arabinar A (eds) Proceedings of the 10th Salzburg conference on cerebral vascular disease. Amsterdam: Excerpta medica, 1981, p 3
Leblanc R, Feindel W, Yamamoto LY, Milton JG, Frojmovic MM, Hodge CP (1984) The effects of calcium antagonism on the epicerebral circulation in early vasospasm. Stroke 15:1017–1020
McCalden TA, Nath RO, Thiele K (1984) The effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonists. Stroke 15:527–530
Möhr JP, Caplan LR, Melski JW, Duncan GW, Kistler JP, Pessin MS, Goldstein RJ, Bleich HL (1978) The Harvard cooperative stroke registry: a prospective registry of cases hospitalized with stroke. Neurology 28:754–762
Rosenblum WI (1984) Effects of calcium channel blockers on pial vascular responses to receptor mediated constrictors. Stroke 15:284–288
Seelig JM, Wei EP, Kontos HA, Becker DP (1983) Effects of changes in magnesium ion concentration on cat cerebral arterioles. Am J Physiol 245:22–26
Shinar D, Gross CR, Mohr JP et al. (1985) Inter-observer variability in the assessment of neurologic history and examination in the Stroke Data Bank. Arch Neurol 42:557–565
Vermeulen M, van Gijn J, Hijdra A, Wijdicks EFM (1983) Nimodipine for cerebral arterial spasm in subarachnoid hemorrhage. (Letter to the editor). N Engl J Med 309:437
Wiernsperger N, Gygax P, Hofmann A (1984) Calcium antagonist PY 108-068: demonstration of its efficacy in various types of experimental brain ischemia. Stroke 15:679–685
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© 1989 Springer-Verlag Berlin Heidelberg
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Mohr, J.P., Muschett, J.L., Riccio, R.V. (1989). Nimodipine Clinical Trial in Acute Ischemic Stroke. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_44
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DOI: https://doi.org/10.1007/978-3-642-85863-5_44
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