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Cerebral Ischemia and Calcium pp 313–322Cite as

Thrombosis on Stenosis: Mechanisms of Thrombus Growth and Embolization on Carotid Atherosclerotic Plaques

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Abstract

The association between carotid artery disease and stroke has long been recognized. Artery to artery embolism is one of several mechanisms causing either transient ischemic attacks (TIAs) or stroke ipsilateral to atherosclerotic plaques [25]. Thrombus at the site of carotid arterial occlusion [12], atherosclerotic debris, and vertebral artery stenosis or occlusion are well-documented sources of emboli [26]. Fibrin-platelet thrombus forms in carotid artery plaques with severe stenosis. These thrombi, when partially or totally dislodged, can produce distal embolism. Ulceration, a frequent finding in carotid plaques, exposes atherosclerotic plaque matrix to flowing blood and leaves behind cavities (changes in plaque morphology) within the plaques, inducing local flow disturbances; both factors independently or associated can trigger thrombosis.

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References

  1. Ambrose JA, Winters SL, Arora RR, Ricio A, Gorlin R, Fuster V (1986) Angiographic evolution of coronary artery morphology in unstable angina. J Am Coll Cardiol 7:472–478

    Article  PubMed  CAS  Google Scholar 

  2. Badimon L, Badimon JJ, Galvez A, Chesebro JH, Fuster V (1986) Influence of arterial damage and wall shear rate on platelet deposition. Arteriosclerosis 6:312–320

    Article  PubMed  CAS  Google Scholar 

  3. Badimon L, Turitto VT, Rosemark JA, Badimon JJ, Fuster V (1987 a) Characterization of a tubular flow chamber for studying platelet interaction with biological and prosthetic materials, J Lab Clin Med 110:706

    PubMed  CAS  Google Scholar 

  4. Badimon L, Badimon JJ, Turitto VT, Rand J, Fuster V (1987b) Platelet deposition on von Willebrand factor deficient vessels. Extracorporeal perfusion studies in swine with von Willebrand’s disease using native and heparinized blood. J Lab Clin Med 110:634

    CAS  Google Scholar 

  5. Badimon L, Badimon JJ, Turitto VT, Fuster V (1987c) Thrombosis: studies under flow conditions. Ann NY Acad Sci 516:527–540

    CAS  Google Scholar 

  6. Badimon L, Badimon JJ, Turitto VT, Vallabhajosula S, Fuster V (1988) Platelet thrombus formation on collagen type. I. Circulation 78:1431–1442

    Article  PubMed  CAS  Google Scholar 

  7. Busuttil RW, Baker JD, Davidson RK, Machleder HI (1981) Carotid artery stenosis-hemodynamic significance and clinical course. JAMA 245:1438–1441

    Article  PubMed  CAS  Google Scholar 

  8. Davies MJ, Thomas AC (1985) Plaque fissuring — the cause of acute myocardial infarction, sudden ischemic death and crescendo angina. Br Heart J 53:363–373

    Article  PubMed  CAS  Google Scholar 

  9. DeWood MA, Spores J, Notske R, Mouser IT, Burroughs R, Golden MS, Lang HT (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303:896–902

    Article  Google Scholar 

  10. Dyken ML, Wolf PA et al. (1985) Special report. Risk factors in stroke. Stroke 6:1105–1111

    Google Scholar 

  11. Falk E (1985) Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Circulation 71:699–708

    Article  PubMed  CAS  Google Scholar 

  12. Finklestein S, Kleinmann GM, Cuneo R, Baringer JR (1980) Delayed stroke following carotid occlusion. Neurology (Minneap) 30:84–88

    Article  CAS  Google Scholar 

  13. Fuster V, Chesebro JH (1986) Mechanism of unstable angina. N Engl J Med 315:1023–1024

    Article  PubMed  CAS  Google Scholar 

  14. Fuster V, Badimon L, Badimon JJ, Adams PC, Turitto VT, Chesebro JH (1987) Drugs interfering with platelet functions: mechanisms and clinical relevance. In: Veerstraete M, Vermylen J, Liujnen R, Arnout J (eds) Thrombosis and haemostasis. Leuven University Press, pp 349–418

    Google Scholar 

  15. Gomensoro JB, Maslenikov V, Azambuja N, Fields WS, Lemak N (1973) Joint study of extracranial arterial occlusion. JAMA 224:985–991

    Article  PubMed  CAS  Google Scholar 

  16. Gorlin R, Fuster V, Ambrose JA (1986) Anatomic-physiologic links between acute coronary syndromes. Circulation 74:6–9

    Article  PubMed  CAS  Google Scholar 

  17. Hass WK, Fields WS, North RR, Kricheff II, Chase NE, Bauer RB (1968) Joint study of extracranial arterial occlusion. JAMA 203:159–166

    Article  Google Scholar 

  18. Imparato AM, Riles TS, Mintze KR, Baumann FG (1983) The importance of hemorrhage in the relationship between gross morphologic characteristics and cerebral symptoms in 376 carotid artery plaques. Ann Surg 197:195–203

    Article  PubMed  CAS  Google Scholar 

  19. Kricheff II (1987) Arteriosclerotic ischemic cerebrovascular disease. Radiology 162:101–109

    PubMed  CAS  Google Scholar 

  20. Lusby RJ, Ferrell LD, Ehrenfeld WK, Stoney RJ, Wylie EJ (1982) Carotid plaque hemorrhage: its role in production of cerebral ischemia. Arch Surg 117:1479–1488

    Article  PubMed  CAS  Google Scholar 

  21. Moore WS, Hall AD (1968) Ulcerated atheroma of the carotid artery. Am J Surg 116:237–242

    Article  PubMed  CAS  Google Scholar 

  22. Moore WS, Hall AD (1970) Importance of emboli from carotid bifurcation in pathogenesis of cerebral ischemic attacks. Arch Surg 101:708–711

    Article  PubMed  CAS  Google Scholar 

  23. Raichle ME (1983) The pathophysiology of brain ischemia. Ann Neurol 13:2–10

    Article  PubMed  CAS  Google Scholar 

  24. Rentrop P, Blanke H, Karsch K, Kaiser H, Kostering H, Leitz K (1981) Selective intracoronary thrombosis in acute myocardial infarction and unstable angina pectoris. Circulation 63:307–316

    Article  PubMed  CAS  Google Scholar 

  25. Thiele BL, Young JV, Chikos PM, Hirsch JH, Strandness DE (1980) Correlation of artériographic findings and symptoms in cerebrovascular disease. Neurology 30:1041–1046

    Article  PubMed  CAS  Google Scholar 

  26. Wechsler LR (1987) Ulceration and carotid artery disease. Curr Concepts Cerebrovasc Dis 22:19–23

    Google Scholar 

  27. Weinberger J, Robbins A (1983) Neurologic symptoms associated with nonobstructive plaque at carotid bifurcation. Analysis by real-time B-mode ultrasonography. Arch Neurol 40:489–492

    Article  PubMed  CAS  Google Scholar 

  28. Weinberger J, Marks SJ, Gaul JJ, Goldman B, Schanzer H, Jacobson JJ, Dikman S (1987) Atherosclerotic plaque at the carotid artery bifurcation: correlation of ultrasonographic imaging with morphology. J Ultrasound Med 6:363–366

    PubMed  CAS  Google Scholar 

  29. Weinberger J, Ramos L, Ambrose JA, Fuster V (1988) Morphology and dynamic changes of atherosclerotic plaque at the carotid artery bifurcation: sequential imaging by real time B-mode ultrasonography (submitted)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Cardiology, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY, 10029, USA

    L. Badimon, J. J. Badimon, R. Lassila, V. T. Turitto & V. Fuster

Authors
  1. L. Badimon
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  2. J. J. Badimon
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  3. R. Lassila
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  4. V. T. Turitto
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  5. V. Fuster
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut der Universität, Im Neuenheimer Feld 326, D-6900, Heidelberg, Germany

    Wolfgang Kuschinsky

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© 1989 Springer-Verlag Berlin Heidelberg

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Badimon, L., Badimon, J.J., Lassila, R., Turitto, V.T., Fuster, V. (1989). Thrombosis on Stenosis: Mechanisms of Thrombus Growth and Embolization on Carotid Atherosclerotic Plaques. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_40

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  • DOI: https://doi.org/10.1007/978-3-642-85863-5_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85865-9

  • Online ISBN: 978-3-642-85863-5

  • eBook Packages: Springer Book Archive

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