Skip to main content
SpringerLink
Log in
Book cover

Cerebral Ischemia and Calcium pp 307–312Cite as

The Effect of Calcium Antagonists in Experimental Atherosclerosis, the Underlying Cause of Heart and Cerebral Vascular Diseases

  • Conference paper

  • 155 Accesses

Abstract

Migration and proliferation of arterial smooth muscle cells (SMCs) into the intima are considered important events in the development of atherosclerosis, the underlying cause of coronary and cerebral vascular diseases [18, 20]. A variety of different atherosclerotic risk factors stimulate these cellular reactions. In response to experimental stimulations [7, 10, 12], SMCs migrate through the fenestrae of the internal elastic lamina, appear at the luminal surface, and form an intimal thickening that displays many features of an atherosclerotic plaque.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Betz E, Hämmerle H, Viele D (1984) Ca2+-entry blockers and atherosclerosis. Int Angiol 3:33–44

    Google Scholar 

  2. Betz E, Hämmerle H, Strohschneider T (1985) Inhibition of smooth muscle cell proliferation and endothelial permeability with flunarizine in vitro and in experimental atheromas. Res Exp Med 185:325–340

    Article  CAS  Google Scholar 

  3. Brecher P, Chan CT, Franzblau C, Faria B, Chobanian AV (1978) Effect of hypertension and its reversal on aortic metabolism in the rat. Circ Res 43:561–569

    Article  PubMed  CAS  Google Scholar 

  4. Cassel D, Rothenberg P, Zhuang Y, Deuel TF, Glaser L (1983) Platelet-derived growth factor stimulates Na++/H+ exchange and induces cytoplasmic alkalinization in NR6 cells. Proc Natl Acad Sci USA 80:6224–6330

    Article  PubMed  CAS  Google Scholar 

  5. Chalouleas JG, Bolton WE, Hidaka H, Boyd Ae, Means AR (1982) Calmodulin and the cell cycle — involvement in regulation of cell-cycle progression. Cell 28:41–47

    Article  Google Scholar 

  6. Eichelbaum M, Echizen H (1984) Clinical pharmacology of calcium antagonists: a critical review. J Cardiovasc Pharmacol 6:963–967

    Article  Google Scholar 

  7. Grünwald J, Robenek H, Mey J, Hauss WH (1982) In vivo and in vitro cellular changes in experimental hypertension. Exp Mol Pathol 36:164–176

    Article  PubMed  Google Scholar 

  8. Grünwald J, Haudenschild CC (1984) Intimai injury in vivo activates vascular smooth muscle cell migration and expiant outgrowth in vitro. Arteriosclerosis 4:183–189

    Article  PubMed  Google Scholar 

  9. Grünwald J, Haudenschild CC (1985) The influence of antiplatelet drugs on balloon injury stimulated migration in cultured smooth muscle cells. Artery 12:324–336

    PubMed  Google Scholar 

  10. Grünwald J, Chobanian AV, Haudenschild CC (1987) Smooth muscle cell migration and proliferation: atherogenic mechanism in hypertension. Atherosclerosis 67:215–221

    Article  PubMed  Google Scholar 

  11. Grünwald J (1987) Time-lapse video microscopic analysis of cell proliferation, motility and morphology: applications for cytopathology and pharmacology. Biotechniques 5:680–687

    Google Scholar 

  12. Grünwald J, Fingerle J, Hämmerle H, Betz E, Haudenschild CC (1987) Cytocontractile structures and proteins of smooth muscle cells during the formation of experimental lesions. Exp Mol Pathol 46:78–88

    Article  PubMed  Google Scholar 

  13. Kaul D, Kukreja RS (1987) Atherogenesis. Prevention action of trifluoperazine. Atherosclerosis 64:211–214

    Google Scholar 

  14. Nakayama K, Kasuja Y (1980) Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine. Jpn J Pharmacol 30:731–737

    Article  PubMed  CAS  Google Scholar 

  15. Nilsson J, Sjölund M, Palmberg L, von Euler AM, Jonzon B, Thyberg J (1985) The calcium antagonist nifedipine inhibits arterial smooth muscle cell proliferation. Atherosclerosis 58:109–122

    Article  PubMed  CAS  Google Scholar 

  16. Van Nueten JM, Van Beek J, Janssen PA (1978) Effect of flunarizine on calcium-induced responses of peripheral vascular smooth muscle. Arch Int Pharmacodyn Ther 232:42–52

    PubMed  Google Scholar 

  17. Page JH, Graef J (1939) Hypertension following experimental perinephritis induced by cellophane. Arch Pathol 28:613

    Google Scholar 

  18. Ross R, Glomsett JA (1973) Atherosclerosis and the arterial smooth muscle cell. Science 180:1332–1339

    Article  PubMed  CAS  Google Scholar 

  19. Stoclet JC, Lugnier C, Follenius A, Scheftel JM, Gerhard D (1985) Calmodulin and calcium regulation: effect of antagonists. In: Te PM, Govoni S, Paoletti R (eds). Raven, New York, pp 31–40

    Google Scholar 

  20. Wissler RW (1968) The arterial medial cell, the smooth muscle cell or multifunctional mesenchyme? J Atheroscl Res 8:201–213

    Article  Google Scholar 

  21. Van Zwieten PA (1985) Calcium-Antagonisten — Terminologie, Klassifizierung und Vergleich. Arzneimittelforschung/Drug Res 35:298–301

    Google Scholar 

Download references

Author information

Author notes

  1. J. Grünwald

    Present address: Lichtwer Pharma, D-1000, Berlin 28, Germany

Authors and Affiliations

  1. Institute for Arteriosclerosis Research, University of Münster, Domagkstr. 3, D-4400, Münster, Germany

    J. Grünwald

  2. Department of Anatomy and Histology, Varna Institute of Medicine, BG-Varna, Bulgaria

    G. N. Chaldakov

  3. Mallory Institute for Pathology, Boston University, 784 Massachusetts Avenue, Boston, MA, 02118, USA

    Ch. C. Haudenschild

Authors
  1. J. Grünwald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. N. Chaldakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ch. C. Haudenschild
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut der Universität, Im Neuenheimer Feld 326, D-6900, Heidelberg, Germany

    Wolfgang Kuschinsky

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Grünwald, J., Chaldakov, G.N., Haudenschild, C.C. (1989). The Effect of Calcium Antagonists in Experimental Atherosclerosis, the Underlying Cause of Heart and Cerebral Vascular Diseases. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85863-5_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85865-9

  • Online ISBN: 978-3-642-85863-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation