Abstract
With the development of radio-active particles, investigators [1, 2, 4, 5, 6, 8, 10] have been re-examining regional distribution of the cardiac output (C.O.) to organs and tissues, including the brain of experimental animals. Carbonized microspheres appeared to be distributed in direct proportion to blood flow (BF) and by appropriate size selection, essentially all can be removed in one circulation. Preliminary studies [9] were performed to examine regional BF and total brain flow (TBF) in the dog brain. These have been extended and the effect of breathing 5% CO2 on BF has been studied [10]. External isotope monitoring to detect the washout of residual (r) radioactivity of an inert gas in a tissue has become an important tecnique to study regional BF. Many investigators [3, 4, 7 and others] have used this approach to examine cerebral blood flow (CBF). This study proposed to determine regional and TBF by particle distribution method and also analyze cortical blood flow by the rCBF approach using 133Xe to provide a comparative study.
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References
Flohr, H. W.: Methode zur Messung regionaler Durchblutungsgrößen mit radioaktiv markierten Partikeln. Europ. J. Physiol. 302, 268 (1968).
Forsyth, R. P., A. S. Nies, J. Neutze, and K. L. Melmon: Normal distribution of cardiac output in the unanesthetized, restrained Rhesus monkey. J. appl. Physiol. 25, 736 (1968).
Häggendal, E., and B. Johansson: Effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow autoregulation. Acta Physiol, scand. 66, suppl. 258, 25 (1965).
Høedt-Rasmussen, K., E. Sveinsdottir, and N. A. Lassen: Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas. Circulat. Res. 18, 237 (1966).
Kaihara, S., P. D. Van Heerlen, T. Migita, and H. N. Wagner, Jr.: Measurement of distribution of cardiac output. J. appl. Physiol. 25, 696 (1968).
Neutze, J. M., F. Wyler, and A. M. Rudolph: Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Amer. J. Physiol. 215, 486 (1968).
Obrist, W. D., H. K. Thompson, C. H. King, and H. S. Wang: Determination of regional cerebral blood flow by inhalation of Xe133. Qrculat. Res. 20, 124 (1967).
Rudolph, A. M., and M. A. Heyman: The circulation of the fetus in utero. Circulat. Res. 21, 163 (1967).
Tschetter, T., M. Meyer, A. Klassen, and J. Resch: Regional cerebral blood flow using labeled microspheres. Proc. Int. Union of Physiol. Sc. 7, 441 (1968).
Tschetter, T., A. Klassen, J. Resch, and M. Meyer: In preparation.
Veall, N., and B. L. Mallet: Regional cerebral blood flow determination by 133Xe inhalation and external recording: the effect of arterial recirculation. Clin. Sci. 30, 353 (1966).
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Meyer, M., Tschetter, T., Klassen, A., Resch, J. (1969). Regional Brain Blood Flow Estimated by Using Particle Distribution and Isotope Clearance Methods. In: Brock, M., Fieschi, C., Ingvar, D.H., Lassen, N.A., Schürmann, K. (eds) Cerebral Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85860-4_18
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DOI: https://doi.org/10.1007/978-3-642-85860-4_18
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