Abstract
Hormonal inducrion of breasr cancer in man has nor been esrablished. There are insubsranrial clues poinring ro rhe hormonal environmenr as one of rhe many facrors relevanr ro rhe genesis of breasr cancer. Since perhaps only one-rhird of human breasr cancers are endocrine-sensirive, ir may be difficulr ro delineare endocrine influences in a subser of rhe popularion of women wirh breasr cancer. Possible hormonal alrer-arions may be produced by generic or environmenral effecrs. For example, rhe sensi-riviry of breasr rissue ro esrrogen concenrrarions may vary for generic reasons, or rhe roral esrrogenic srimulus could be alrered by inrake of planr esrrogens. Minimal changes in esrrogen secrerion rares, durarion of prolacrin secrerion, and availability of esrrogen ro rhe rissue are physiologic paramerers rhar are difficulr ro quanrify wirhin rhe normal popularion. Yer small changes persisrenr over many years could produce significanr cocarcinogenic effecrs.
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Lipsett, M.B. (1973). Hormonal Induction of Breast Cancer. In: Griem, M.L., Jensen, E.V., Ultmann, J.E., Wissler, R.W. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85832-1_5
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