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Das Renin-Angiotensin-System, Molekularbiologie und Pharmakologie — Was gibt es Neues?

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Blutdrucksenkung heute — Korrektur von Struktur und Funktion der Arterie

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Zusammenfassung

Das Renin-Angiotensin-System (RAS) ist ein wichtiges Effektorsystem in der Regulation des Blutdrucks und der Salz- und Wasserhomöostase. Das Glykoprotein Angiotensinogen ist hierbei der Ausgangspunkt: das Protein wird in der Leber synthetisiert und in das Blut abgegeben, wo es das Substrat für Renin darstellt. Renin wird von den juxtaglomerulären Zellen der Niere synthetisiert, gespeichert und sezerniert, und spaltet von Angiotensinogen das Dekapeptid Angiotensin I ab. Angiotensin I wird schließlich durch eine Dipeptidylpeptidase (Angiotensin-Konvertingenzym) in das Effektorpeptid des RAS, das Angiotensin II überführt (Abb. 1).

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Authors
  1. N. Niedermaier
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  2. M. Feldmer
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  3. D. Ganten
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Editor information

Editors and Affiliations

  1. Medizinische Poliklinik, Universität Bonn, Wilhelmstr. 35-37, W-5300, Bonn 1, Bundesrepublik Deutschland

    Klaus O. Stumpe

  2. Medizinische Klinik, Städtische Kliniken Dortmund, Beurhausstr. 40, W-4600, Dortmund 1, Bundesrepublik Deutschland

    Dieter Klaus

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© 1990 Springer-Verlag Berlin Heidelberg

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Niedermaier, N., Feldmer, M., Ganten, D. (1990). Das Renin-Angiotensin-System, Molekularbiologie und Pharmakologie — Was gibt es Neues?. In: Stumpe, K.O., Klaus, D. (eds) Blutdrucksenkung heute — Korrektur von Struktur und Funktion der Arterie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85813-0_1

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  • DOI: https://doi.org/10.1007/978-3-642-85813-0_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53417-4

  • Online ISBN: 978-3-642-85813-0

  • eBook Packages: Springer Book Archive

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