Laser Treatment of Experimental Animal Cancer

  • Leon Goldman


The oncologist will find himself confused in experimental animal work with lasers unless he has training in laser technology and expert advice and suggestions. This has been the pattern today in cooperative studies of laser research of experimental cancer in animals as illustrated by the pioneering studies of McGuff and his group, by Klein and Fine and their associates, by Minton and Ketcham and by Rounds and Chamberlin. These exellent basic investigations both in laser radiation of tissue cultures of malignant cells and of experimental cancer in animals have shown varied patterns of effects of laser on cancer. According to Fine and Klein, the effect of the laser treatment of cancer in animals has extended “... from complete regression to accelerated deterioration of the tumorbearing host.” Again, these experiments show, as expected, that the color and consistencey of tissue affects the results.


Laser Radiation Laser Treatment Ruby Laser High Energy Laser Animal Cancer 
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  1. Bach, J. L.: The amazing laser, medicine’s newest research tool. New Physician, 13: 178, 1964.PubMedGoogle Scholar
  2. Blaney, D. J.:Personal communication.Google Scholar
  3. Brown, T.: Personal communication.Google Scholar
  4. Cromwell, N. H.: Chemical carcinogens, carcinogenesis and carcinostasis. American Scientist, 53: 213, 1965.PubMedGoogle Scholar
  5. Fine, S., T. H. Maiman, E. Klein, and R. E. Scott: Biological effects of high peak power radiation. Life Sci., 3: 209, 1964.PubMedCrossRefGoogle Scholar
  6. Goldman, L.: Laser cancer research. Springer-Verlag New York Inc., 1966.Google Scholar
  7. Helsper, J. T., G. S. Sharp, H. F. Williams, and H. W. Fister: The biological effect of laser energy on human melanoma. Cancer, 17: 1299, 1964.PubMedCrossRefGoogle Scholar
  8. Hoye, R. C. and J. P. Minton: The noble gas ion laser as a light knife. Surgical Forum, 16: 92, 1965.Google Scholar
  9. Klein, E., S. Fine, Y. Laor, M. S. Litwin, J. Donoghue, and L. Simpson: Laser irradiation of the skin. Journ. Invest. Derm., 43: 505, 1964.Google Scholar
  10. L. Simpson, J. Ambrus, W. Richter, G. K. Smith, and C. Aaronson: Interaction of laser radiation with biologic systems: II Experimental tumors. Fed. Proc., 24: 143, 1965.PubMedGoogle Scholar
  11. R. E. Scott and S. Farber: Proc. Am. Assoc. Cancer Res., 5: 35, 1964.Google Scholar
  12. McGuff, P.: Laser—A Surgical Tool. Exhibit A.M.A. June, 1965.Google Scholar
  13. McGuff, P.: Comparative study of laser and x-ray radiation. 11th International Congress of Radiology, Rome, 1965.Google Scholar
  14. E. Bushnell, H. Soroff, and R. Deterling, Jr.: Studies of surgical appli-cations of laser. Surg. For., 14: 143, 1963.Google Scholar
  15. R. Deterling, Jr., R. Gottlieb, D. Bushnell, F. Roeber, and H. Fahimi: Laser radiation of malignancies. Ann. N.Y. Acad. Sci., 122: 747, 1965.PubMedGoogle Scholar
  16. H. Fahimi, D. Bushnell, and F. Roeber: The laser treatment of experimental malignant tumors. Can. Med. Ass. J., 91: 1089, 1964.PubMedGoogle Scholar
  17. H. Fahimi, D. Bushnell, and F. Roeber: Effects of laser radiation of tumor transplants. Fed. Proc, 24:150, 1965.PubMedGoogle Scholar
  18. Minton, J. P.: A method to determine laser wavelength absorption capabilities of experimental malignant tumors. Life Sci., 3: 1007, 1964.PubMedCrossRefGoogle Scholar
  19. Minton, J. P.: Some factors affecting tumor response after laser radiation. Fed. Proc., 24: 155, 1965.PubMedGoogle Scholar
  20. Minton, J. P. and A. S. Ketcham: The effect of ruby laser radiation on the Cloudman S-9I melanoma in the CDBA/2F1 hybrid mouse. Cancer, 17: 1305, 1964.PubMedCrossRefGoogle Scholar
  21. Thelaser: A unique oncolytic entity. Amer. J. Surg., 108: 845, 1964.CrossRefGoogle Scholar
  22. J. R. Dearman: Tumoricidal factor in laser radiation. Surg. For., 15: 255, 1964.Google Scholar
  23. J. R. Dearman: The effect of neodymium laser radiation on two ex-perimental malignant tumor systems. Surg. Gyn. Obst., 120: 481, 1965.PubMedGoogle Scholar
  24. J. R. Dearman and W. B. McKnight: The application of pulsed high energy laser radiation to multiple intra-abdominal tumor implants in experimental animals. Surgery, 58: 12, 1965.PubMedGoogle Scholar
  25. C. D. Moody, J. R. Dearman, W. B. McKnight, and A. S. Ketcham: An evaluation of the physical response of malignant tumor implants to pulsed laser radiation. Surgery 121: 538, 1965.Google Scholar
  26. G. H. Weiss, and M. Zelen: Oncolysis with laser energy combined with chemotherapy. Nature, 207: 140, 1965.PubMedCrossRefGoogle Scholar
  27. G. H. Weiss, and M. Zelen: A method for predicting malignant tumor destruction by laser radiation. J. Nat. Cancer Inst., 34: 291, 1965.Google Scholar
  28. G. H. Weiss and A. S. Ketcham: Experimental results from exposure of Cloudman S-91 melanoma in the CDBA/2F1 hybrid mouse to neodymium or ruby laser radiation. Ann. N.Y. Acad. Sci., 122: 758, 1956.Google Scholar
  29. G. H. Weiss and A. S. Ketcham: Some factors affecting tumor response after laser radi-ation. Fed. Proc., 24: 155, 1965.Google Scholar
  30. Swarm, R. F.: Personal communication.Google Scholar

Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • Leon Goldman
    • 1
    • 2
  1. 1.Laser Laboratories, Children’s Hospital Research Foundation and Medical CenterUniversity of CincinnatiUSA
  2. 2.Department of Dermatoloty, College of MedicineUniversity of CincinnatiUSA

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