Immunological Approaches to the Study of Viral Antigens Associated with Neoplasms
Advances in tumor virology and tumor immunology during the past 6 years or so have been characterized by 2 major achievements. One was the demonstration that in some SV40-induced tumors the entire viral genome may persist in the transformed cells in a non-infectious and non-antigenic state (1). The other landmark was the discovery in most virus-induced tumors of 2 types of antigens—the transplantation antigens located on the cell surface and the intracellular T- or neoantigens. Both of these antigens are considered to be products specified by the viral genome, suggesting that most virus-induced tumors are characterized by the persistence of a portion of the viral genome as a heritable factor in the transformed cells (2).
KeywordsInfectious Virus Polyoma Virus Transplantation Antigen Hamster Tumor Entire Viral Genome
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