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Studies on the Anti-Tumor Action of Poly I: Poly C

  • H. B. Levy
  • R. Adamson
  • P. Carbone
  • V. DeVita
  • A. Gazdar
  • J. Rhim
  • A. Weinstein
  • F. Riley

Abstract

During the past year there has been a good deal of interest in various aspects of the antitumor action of poly I:poly C., ranging from basic studies of the mechanism of its action to the beginning of therapeutic trials in humans with malignant disease. This discussion will touch on both of these areas of interest.

Keywords

Antitumor Action Newcastle Disease Virus Interferon Treatment Reticulum Cell Sarcoma Baby Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gresser, I., Coppey, J., Fontaine-Brouty-Boye, D., Falcoff, R., Falcoff, E., and Zajdela, A. (1967). Interferon and murine leukaemia. III: Efficacy of interferon preparations administered after inoculation of Friend virus. Nature 215: 174.PubMedCrossRefGoogle Scholar
  2. Levy, H. B., Asofsky, R., Riley, F., Garapin, A., Cantor, H., and Adamson, R. (1969). The antitumor action of polyinosinic-polycytidylic acid. Ann. N.Y. Acad. Sci., in press.Google Scholar
  3. Levy, H. B., Law, L. W., and Rabson, A. S. (1969). Inhibition of tumor growth by polyinosinic-polycytidylic acid. Proc. Natl. Acad. Sci. U.S. 62: 357.CrossRefGoogle Scholar
  4. Nordlund, J. J., Wolff, S. M., and Levy, H. B. (1970). Inhibition of biologic activity of poly I: poly C by human plasma. Proc. Soc. Exptl. Biol. Med. 133: 439.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1971

Authors and Affiliations

  • H. B. Levy
    • 1
  • R. Adamson
    • 2
  • P. Carbone
    • 2
  • V. DeVita
    • 2
  • A. Gazdar
    • 2
  • J. Rhim
    • 3
  • A. Weinstein
    • 2
  • F. Riley
    • 1
  1. 1.National Institute of Allergy & Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Microbiological AssociatesBethesda

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