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Biological Effects of Polynucleotides pp 259–273Cite as

Polyinosinic-Polycytidylic Acid Toxicity

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Abstract

This report deals mainly with the pathological effects of polyinosinic-polycytidylic acid, poly (rI · rC), given in lethal or near lethal doses. The work was done to obtain information about the potential of the complexes for inducing dangerous toxicity in patients who might receive the agent in clinical trials against cancer. The experimental species studied included mice, rats, rabbits, and dogs.

Supported in part by Grant CA 08748 from the National Cancer Institute, USPHS, and by the U.S. Atomic Energy Commission.

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References

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Author information

Authors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Memorial Hospital for Cancer and Allied Diseases, New York, New York, USA

    Frederick S. Philips, Martin Fleisher, L. D. Hamilton, Morton K. Schwartz & Stephen S. Sternberg

  2. Brookhaven National Laboratory, Upton, New York, USA

    Frederick S. Philips, Martin Fleisher, L. D. Hamilton, Morton K. Schwartz & Stephen S. Sternberg

Authors
  1. Frederick S. Philips
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  2. Martin Fleisher
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  3. L. D. Hamilton
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  4. Morton K. Schwartz
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  5. Stephen S. Sternberg
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Editor information

Editors and Affiliations

  1. Johns Hopkins University, Baltimore, Maryland, USA

    Roland F. Beers Jr.

  2. Rutgers University, New Brunswick, New Jersey, USA

    Werner Braun

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© 1971 Springer-Verlag New York Inc.

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Philips, F.S., Fleisher, M., Hamilton, L.D., Schwartz, M.K., Sternberg, S.S. (1971). Polyinosinic-Polycytidylic Acid Toxicity. In: Beers, R.F., Braun, W. (eds) Biological Effects of Polynucleotides. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85772-0_18

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  • DOI: https://doi.org/10.1007/978-3-642-85772-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85774-4

  • Online ISBN: 978-3-642-85772-0

  • eBook Packages: Springer Book Archive

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