A New Family of Pore Forming Proteins, the Perforin Family, in Immune Cytolysis by Complement and by Lymphocytes

  • Eckhard R. Podack
Conference paper
Part of the NATO ASI Series book series (volume 24)

Abstract

Immune cytolysis is effected by the complement proteins and by cytolytic lymphocytes. Target destruction by these humoral and cellular immune defense systems is mediated, in part, by pore forming proteins assembling transmembrane tubules on target membranes (for review see 1–5). Perforation of the membrane results in loss of membrane potential, dissipation of transmembrane ionic gradients, Ca-ion entry into target cells, loss of macromolecular cellular compounds and the eventual death of the target cell.

Keywords

Migration Albumin Cysteine Electrophoresis Polypeptide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Eckhard R. Podack
    • 1
  1. 1.New York Medical CollegeDepartment of Microbiology and ImmunologyValhallaUSA

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