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Changes in Fast-Transported Protein in Regenerating Axons: Essential or Incidental?

  • Conference paper
Book cover Axoplasmic Transport in Physiology and Pathology

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Following axotomy and during subsequent axon regeneration, the cell bodies of peripheral neurons undergo structural and metabolic changes known as“chromatolysis”, including an alteration in protein synthesis patterns of the cell bodies. Synthesis f transmitter-related enzymes decreases while that of structural proteins increases [15]. Changes in the composition of fast transported protein might be expected when the axon is elongating instead of transmitting to the target cell; thus, changes in the transport of specific transmitter-related enzymes have been reported [17, 21, 23, 24, 32]. The study of changes in the transport of total transported proteins might provide information about the functions of some of the transported proteins, and conversely, about the role of fast axonal transport in axon regeneration.

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Author information

Authors and Affiliations

  1. Dept. of Medical Physiology, Faculty of Medicine, University of Calgary, Calgary, Alta, T2N 4N1, Canada

    Mark A. Bisby

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  1. Mark A. Bisby
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Editor information

Editors and Affiliations

  1. Zoologisches Institut, Universität München, Luisenstraße 14, 8000, München 2, Germany

    Dieter G. Weiss

  2. Department of Cytopharmacology, Fidia Research Laboratories, Abano Terme, Padova, Italy

    Alfredo Gorio

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© 1982 Springer-Verlag Berlin Heidelberg

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Bisby, M.A. (1982). Changes in Fast-Transported Protein in Regenerating Axons: Essential or Incidental?. In: Weiss, D.G., Gorio, A. (eds) Axoplasmic Transport in Physiology and Pathology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85714-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-85714-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85716-4

  • Online ISBN: 978-3-642-85714-0

  • eBook Packages: Springer Book Archive

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