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Classification of Antiarrhythmic Drugs: How Do We Educate the Scientist and the Clinician

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Antiarrhythmic Drugs

Abstract

In U. S. medical schools, the teaching of electrophysiology and of cardiac arrhythmias and their treatment commences with the physiology and pharmacology courses presented during the first two years of the curriculum. Following a physician’s graduation from medical school, instruction with respect to arrhythmias and their therapy resides largely in modified “apprenticeships” during internship, residency and fellowship years. There is little in the way of formal curriculum, and programs vary greatly in the content and method of their teaching. Despite this variability, the numbers of patients hospitalized with cardiac disease are sufficient to continually confront the trainee with the complexities that surround the causes, diagnoses and treatment of arrhythmias.

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References

  1. Hoffman BF, Rosen MS (1981) Cellular mechanism for cardiac arrhythmias. Circ Res 49: 1–15

    Article  PubMed  CAS  Google Scholar 

  2. DiFrancesco D (1985) The cardiac hyperpolarizing-activated current, If. Origins and developments. Prog Biophys Mol Biol 46: 163–183

    Article  PubMed  CAS  Google Scholar 

  3. Katzung BG, Morgenstern JA (1977) Effects of extracellular potassium on ventricular automaticity and evidence for a pacemaker current in mammalian ventricular myocardium. Circ Res 40: 104–111

    Article  Google Scholar 

  4. Wit AL, Rosen MR (1991) Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism In: 2nd edn, vol 2. Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds), Raven, New York, pp 2113–2163

    Google Scholar 

  5. Wit AL, Janse MJ (eds) (1993)The ventricular arrhythmias of ischemia and infarction: electrophysiological mechanisms. Futura, Mount Kisco Publishing, 1993

    Google Scholar 

  6. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology (1991) The Sicilian Gambit. Circulation 84: 1831–1851

    Google Scholar 

  7. The Cardiac Arrhythmia Suppression Trial (CAST) investigators (1989) Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 21: 406–412

    Google Scholar 

  8. Mason JW (for the Electrophysiologic Study vs. Electrocardiographic Monitoring Investigators)(1993) A comparison of electrophysiologic testing with Holter monitoring to predict antiarrhythmic drug efficacy for ventricular tachyarrhythmias. N Engl J Med 329: 445–451

    Google Scholar 

  9. Mason JW (for the Electrophysiology Study vs. Electrocardiographic Monitoring Investigators) (1993) A comparison of seven antiarrhythmic drugs in patients with ventricular tachyarrhythmias. N Engl J Med 329: 452–458

    CAS  Google Scholar 

  10. Bigger JT Jr, Hoffman BF (1990) Antiarrhythmic drugs. In: The pharmacological basis of therapeutics, 8th edn. Gilman AG, Rall TW, Nies AS, Tayler P (eds) Pergamon, New York, pp 840–873

    Google Scholar 

  11. Vaughan Williams EM (1970) Classification of antiarrhythmic drugs. In: Sandoe E, Flensted-Jensen E, Olsen KH (eds) Cardiac arrhythmias. Astra, Sodertalje, pp 449–472

    Google Scholar 

  12. Honerjäger P (1990) Neue Aspekte der molekularen Wirkung von Antiarrhythmika. Herz 15: 70–78

    PubMed  Google Scholar 

  13. The Sicilian Gambit (CD ROM) (1993) An educational service from Knoll, Ludwigshafen

    Google Scholar 

  14. Schwartz PT, Zaza A (1992) The Sicilian Gambit revisited-Theory and practice. Eur Heart J 13 [Suppl F]: 26

    Google Scholar 

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© 1995 Springer-Verlag Berlin Heidelberg

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Rosen, M.R. (1995). Classification of Antiarrhythmic Drugs: How Do We Educate the Scientist and the Clinician. In: Breithardt, G., Borggrefe, M., Camm, A.J., Shenasa, M., Haverkamp, W., Hindricks, G. (eds) Antiarrhythmic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85624-2_20

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  • DOI: https://doi.org/10.1007/978-3-642-85624-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85626-6

  • Online ISBN: 978-3-642-85624-2

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