Vergleich zellkinetischer Parameter menschlicher Knochenmarkszellen nach Entnahme mittels Aspiration oder Biopsie

  • W. Hiddemann
  • T. Büchner
  • B. Wörmann
  • W. Göhde
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für innere Medizin book series (VDGINNERE, volume 85)

Zusammenfassung

Bei Patienten mit akuten Leukämien wurden zellkinetische Parameter an Knochenmarkszellen in einer Reihe von Publikationen sowohl im Hinblick auf prätherapeutische prognostische Faktoren als auch im Rahmen eines zellkinetischen Monitorings der cytostatischen Therapie untersucht [1,2,4,5,8-11,14,17,18,22,24,27,29]. Das dazu verwendete Material wurde ausnahmslos durch Knochenmarkaspiration gewonnen. Bei dieser Technik kommt es zu einer unterschiedlich starken Kontamination der Knochenmarkszellen mit peripherem Blut [3, 161. Da sich leukämische Blasten im Blut zum grüBten Teil nicht im Zellzyklus befinden [16], führt ihre Zumischung im Aspirat zu einer relativen Verminderung an Zellen in den Zyklusphasen S, G2 und Mitose und damit zu einer Verfälschung proliferationskinetischer Daten von Knochenmarkszellen.

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Copyright information

© J. F. Bergmann Verlag, München 1979

Authors and Affiliations

  • W. Hiddemann
    • 1
  • T. Büchner
    • 2
  • B. Wörmann
    • 2
  • W. Göhde
    • 3
  1. 1.Med. Univ.-PoliklinikDeutschland
  2. 2.Abt. A, Med. Univ.-KIinikDeutschland
  3. 3.Radiolog. Univ.-Klinik MünsterDeutschland

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