Physiological and Pharmacological Aspects of the Cerebral Circulation with Special Regard to Mental Activity and to Dementia
Since Kety and Schmidt  about three decades ago introduced the nitrous oxide inhalation technique for the measurement of the cerebral blood flow in man, there has been a tremendous increase in our knowledge about the cerebral circulation. The resolution of the flow measurements became much increased with the introduction of the intraarterial injection method by Lassen and Ingvar  which uses a radioactive inert gas as indicator and which subsequently was adapted in man . This method allows the determination of the regional cerebral blood flow simultaneously within multiple areas of the brain. The present paper reviews some of the basic physiological mechanism of importance for the regulation of the cerebral blood flow including recent years’ studies of regional cerebral blood flow changes during various forms for metal activity. Subsequently flow changes in schizophrenia and dementia as well as pharmacological aspects are commented on.
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- Olesen, J.: Cerebral blood flow. Methods for measurement, regulation, effects of drugs and changes in diseases. Acta neurol. scand. 50 (Suppl. 57).Google Scholar
- 8.Paulson, O. B., Sharbrough, F. W.: Physiological and pathophysiological relationship between the electroencephalogram and the regional cerebral blood flow. Acta neurol. scand. 50, 194–220.Google Scholar
- 9.Sokoloff, L.: Local cerebral circulation at rest and during altered cerebral activity induced by anesthesia or visual stimulation. In: Regional neurochemistry (eds. S. S. Kety, J. Elkes), pp. 107–117. New York: Pergamon 1961.Google Scholar
- 13.Larsen, B., Skinhøj, E., Endo, H.: Localization of speech functions as revealed by regional cerebral blood flow measurements with specially reference to the role of the minor hemisphere. Observations in normals and in patients with aphasia. Presented at the 8th Salzburg Conference on Cerebral Vascular Diseases. September 1976.Google Scholar
- 14.Ingvar, D. H.: Patterns of brain activity revealed by measurement of regional cerebral blood flow. In: Brain work (eds. D. H. Ingvar, N. A. Lassen), pp. 397–413. Copenhagen: Munksgaard and New York: Academic Press 1975.Google Scholar