Physiological and Pharmacological Aspects of the Cerebral Circulation with Special Regard to Mental Activity and to Dementia

  • O. B. Paulson
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für innere Medizin book series (VDGINNERE, volume 83)


Since Kety and Schmidt [1] about three decades ago introduced the nitrous oxide inhalation technique for the measurement of the cerebral blood flow in man, there has been a tremendous increase in our knowledge about the cerebral circulation. The resolution of the flow measurements became much increased with the introduction of the intraarterial injection method by Lassen and Ingvar [2] which uses a radioactive inert gas as indicator and which subsequently was adapted in man [3]. This method allows the determination of the regional cerebral blood flow simultaneously within multiple areas of the brain. The present paper reviews some of the basic physiological mechanism of importance for the regulation of the cerebral blood flow including recent years’ studies of regional cerebral blood flow changes during various forms for metal activity. Subsequently flow changes in schizophrenia and dementia as well as pharmacological aspects are commented on.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • O. B. Paulson
    • 1
  1. 1.Dept. of NeurologyRigshospitaletCopenhagenDenmark

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