Viruses and the Kidney
There are several possible mechanisms by which viruses can injure the kidney: 1. Viruses may directly injure kidney tissues. In this way the virus itself, toxic products made by the virus, or cellular enzymes (i. e., lysozymes) released during viral infection may subsequently lead to destruction of infected tissues. 2. Viruses may contain unique antigens that have immunologic identity with structural antigens of the kidney such that the immune responses made against the virus will elicit an antibody that also cross reacts with kidney tissues. A variant on this theme is that virus may uncover or free latent antigens normally hidden in kidney tissue, thus making it accessible to interact with antibody. There is little experimental evidence at present that favors either of the above hypotheses.