Antimicrobial Prophylaxis in Urology: Timing, Dosing, and Duration Studies with special reference to High-risk conditions

  • Thomas C. Gasser
  • Paul O. Madsen
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 27)


A study in guinea pigs was performed to investigate the importance of timing, dosage, and duration of antimicrobial prophylaxis in urologic surgery. To simulate highrisk conditions, in one group a foreign body was implanted subcutaneously. The prostate and one kidney were cauterized and bacteremia was induced by intravenous injection of Escherichia coli solution. Various ciprofloxacin regimen were tested.

The results indicate that antimicrobial prophylaxis is beneficial only if administered before or shortly after surgery. Full therapeutic dosage may not be necessary for prophylactic efficacy. Single dose prophylaxis was as effective as multiple doses. Foreign body infection could be prevented by single-dose prophylaxis.


Foreign Body Antimicrobial Prophylaxis Urologic Surgery Bacterial Challenge Prophylactic Efficacy 
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Copyright information

© Dr. Dietrich SteinkopffVerlag & Co. KG, Darmstadt 1992

Authors and Affiliations

  • Thomas C. Gasser
    • 1
  • Paul O. Madsen
    • 2
  1. 1.Urologie ClinicsUniversity HospitalBaselSwitzerland
  2. 2.VA HospitalMadisonUSA

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