Fleroxacin (Ro 23-6240) Distribution in Canine Prostatic Tissue and Fluids
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The distributiou of Oeroxacin (Ro 23–6240) in canine prostatic tissue and Ouids was investigated under steady-state conditions during intravenous infusion. Mean ratios of Oeroxocin concentration in tissue and Ouids over concentration in plasma were 1.57 ± 0.25 for prostatic tissue, 1.12 ± 0.28 for prostatic secretion, and 0.93 ± 0.14 for prostatic interstitial Ouid. These levels and concentrations in urine were several times higher than the MlC for most pathogens that cause chrouic bacterial prostatitis and urinary tract infection. The MlCs for several isolates of Escherichia coli were only slightly affected by canine prostatic secretion, human prostatic tissue extract, and human urine. Clinical trials with Oeroxacin appear justified for chronic bacterial prostatitis and urinary tract infection,
KeywordsUrinary Tract Infection Human Urine Prostatic Tissue Chronic Bacterial Prostatitis Prostatic Fluid
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