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Quinolone Penetration into Canine Vaginal and Urethral Secretions

  • T. C. Gasser
  • P. H. Graversen
  • E. H. Larsen
  • T. Dørflinger
Chapter
  • 26 Downloads
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 27)

Abstract

Four newer quinolones (amifloxacin, ciprofloxacin, enoxacin, norfloxacin) were administered to female dogs by intravenous infusion. Drug concentrations in plasma, urine, and vaginal and urethral secretion were determined by bioassay. All four quinolones penetrated into vaginal and urethral secretion in concentrations several times higher than the MIC against common urinary pathogens, ciprofloxacin and norfloxacin reaching concentrations exceeding the simultaneous plasma concentrations. Because of their favorable antibacterial spectra, new quinolones should be investigated clinically for the treatment of recurrent urinary tract infection and bacterial vaginitis.

Keywords

quinolones urinary tract infection bacterial vaginitis 

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Copyright information

© Dr. Dietrich SteinkopffVerlag & Co. KG, Darmstadt 1992

Authors and Affiliations

  • T. C. Gasser
    • 1
  • P. H. Graversen
    • 1
  • E. H. Larsen
    • 1
  • T. Dørflinger
    • 1
  1. 1.Urology SectionWilliam S. Middleton Memorial Veterans HospitalMadisonUSA

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