Quinolone Penetration into Canine Vaginal and Urethral Secretions
- 26 Downloads
Four newer quinolones (amifloxacin, ciprofloxacin, enoxacin, norfloxacin) were administered to female dogs by intravenous infusion. Drug concentrations in plasma, urine, and vaginal and urethral secretion were determined by bioassay. All four quinolones penetrated into vaginal and urethral secretion in concentrations several times higher than the MIC against common urinary pathogens, ciprofloxacin and norfloxacin reaching concentrations exceeding the simultaneous plasma concentrations. Because of their favorable antibacterial spectra, new quinolones should be investigated clinically for the treatment of recurrent urinary tract infection and bacterial vaginitis.
Keywordsquinolones urinary tract infection bacterial vaginitis
Unable to display preview. Download preview PDF.
- 6.Stamey TA. Some observations on the pathogenesis of recurrent bacteriuria in women and children. In: Pathogenesis and Treatment of Urinary Tract Infections. Stamey TA (ed). Baltimore, Williams and Wil- kins, 1980 pp 210–289.Google Scholar
- 8.Wolfson JS, Hooper DC. The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro. Antibicrob Agents Chemother 1985;28:581.Google Scholar