Pharmacological aspects of calcium antagonism
My first publication on gallopamil, then still known as substance D 600, appeared about 20 years ago (1). As you know, the first experiments with this new, selective and Ca-competitive group of antagonists were carried out in Professor Fleckenstein’s laboratory in Freiburg. From the start, gallopamil was the most potent Ca antagonist and all other compounds were compared with D 600. Since then the number of experimental and clinical studies on Ca antagonists has grown enormously and they are now virtually impossible to review.
KeywordsCobalt Serotonin Noradrenaline Cytosol Macromolecule
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- 2.Fleckenstein A, Kammermeier H, Döring HJ, Freund HJ (1967) Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig sauerstoffeinsparenden Myokardeffekten, Prenyla-min und Iproveratril. Z Kreislaufforschung 56:716–-744, 839–853Google Scholar
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