Pharmacological aspects of calcium antagonism
My first publication on gallopamil, then still known as substance D 600, appeared about 20 years ago (1). As you know, the first experiments with this new, selective and Ca-competitive group of antagonists were carried out in Professor Fleckenstein’s laboratory in Freiburg. From the start, gallopamil was the most potent Ca antagonist and all other compounds were compared with D 600. Since then the number of experimental and clinical studies on Ca antagonists has grown enormously and they are now virtually impossible to review.
KeywordsSpontaneous Electrical Activity Baroreceptor Reflex Sensitivity Direct Cardiac Effect Border Frequency Contraction Contraction
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- 2.Fleckenstein A, Kammermeier H, Döring HJ, Freund HJ (1967) Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig sauerstoffeinsparenden Myokardeffekten, Prenyla-min und Iproveratril. Z Kreislaufforschung 56:716–-744, 839–853Google Scholar
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- 9.Tritthart HA, Grü;n G, Byon KY, Fleckenstein A (1970) Influence of Ca-antagonistic inhibitors of excitation-contraction coupling on isolated uterine muscle. Studies with the sucrose gap method. Pflügers Arch Eur J Physiol 319:R 117Google Scholar