Pharmacological aspects of calcium antagonism

  • H. A. Tritthart
Conference paper


My first publication on gallopamil, then still known as substance D 600, appeared about 20 years ago (1). As you know, the first experiments with this new, selective and Ca-competitive group of antagonists were carried out in Professor Fleckenstein’s laboratory in Freiburg. From the start, gallopamil was the most potent Ca antagonist and all other compounds were compared with D 600. Since then the number of experimental and clinical studies on Ca antagonists has grown enormously and they are now virtually impossible to review.


Spontaneous Electrical Activity Baroreceptor Reflex Sensitivity Direct Cardiac Effect Border Frequency Contraction Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Fleckenstein A, Tritthart HA, Fleckenstein B, Herbst A, Grün G (1969) Selektive Hemmung der Myokard-Kontraktilität durch kompetitive Ca++-Antagonisten. Naunyn-Schmiedebergs Arch Pharmak 264:227CrossRefGoogle Scholar
  2. 2.
    Fleckenstein A, Kammermeier H, Döring HJ, Freund HJ (1967) Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig sauerstoffeinsparenden Myokardeffekten, Prenyla-min und Iproveratril. Z Kreislaufforschung 56:716–-744, 839–853Google Scholar
  3. 3.
    Ginsburg R, Bristow MR, Harrison DC, Stinson E (1980) Studies with isolated human coronary arteries. Chest 78:180PubMedGoogle Scholar
  4. 4.
    Grün G, Byon KY, Tritthart HA, Fleckenstein A (1970) Inhibition of automatiCity and contractility of isolated human uterine muscle by Ca-antagonistic compounds. Pflü;gers Arch Eur J Physiol 319: R 118Google Scholar
  5. 5.
    Hiramatsu K, Yamagishi F, Kubota T, Yamada T (1982) Acute effects of the calcium antagonist, Nifedipine, on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension. Am Heart J 104:1346–1350PubMedCrossRefGoogle Scholar
  6. 6.
    Millard RW, Gabel M, Fowler NO, Schwartz A (1982) Baroreceptor reflex sensitivity reduced by Diltiazem und Verapamil. Fed Proc 41:57959Google Scholar
  7. 7.
    Nawrath H, Zong Xian-Gang (1983) Elektrophysiologische Untersuchungen mit Gallopamil am Ventrikelmyokard des Menschen. In: Kaltenbach M, Hopf R (eds) Gallopamil, Springer Berlin Heidelberg New York Tokyo, pp. 69–74CrossRefGoogle Scholar
  8. 8.
    Nayler WG, McInnes I, Swann JB, Price JM, Carson V, Race D, Lowe TE (1968) Some effects of iproveratril (Isoptin) on the cardiovascular system. J Pharmacol Exp Ther 161:247–261PubMedGoogle Scholar
  9. 9.
    Tritthart HA, Grü;n G, Byon KY, Fleckenstein A (1970) Influence of Ca-antagonistic inhibitors of excitation-contraction coupling on isolated uterine muscle. Studies with the sucrose gap method. Pflügers Arch Eur J Physiol 319:R 117Google Scholar
  10. 10.
    Winniford M, Markham R, Firth B, Nicod P, Hillis D (1982) Hemodynamic and electrophysiologic effects of Verapamil and Nifedipine in patients on Propranolol Amer J Cardiol 50:704CrossRefGoogle Scholar
  11. 11.
    Koidl B, Tritthart HA (1982) D 600 blocks spontaneous discharge, excitability and contraction of cultured embryonic chick heart cells. J Mol Cell Cardiol 14:251–257PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1989

Authors and Affiliations

  • H. A. Tritthart
    • 1
  1. 1.Institut für medizinische Physik und BiophysikKarl-Franzens-Universität GrazGrazAustria

Personalised recommendations