Abstract
Recombinant DNA technology allows the isolation and precise structural characterization of genes. Reintroduction of genes into intact organisms is now possible, allowing functional analysis of cloned genes and of the physiological consequences of expression of cloned genes [18]. In addition, gene transfer offers the possibility of genetic manipulation of livestock, directing changes as opposed to selecting from existing populations [21].
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References
Ali S, Clark AJ (1988) Characterisation of the gene encoding ß-lactoglobulin: similarity to the genes for retinol binding protein and other secretory proteins. J Mol Biol 199: 415–426
Brem G, Brenig B, Goodman HM, Selden RC, Graf F, Kruff B, Springman K, Hondele J, Meyer J, Winnacker E-L, Kräußlich H (1985) Production of transgenic mice, rabbits and pigs by microinjection into pronuclei. Zuchthygiene 20: 251–252
Brinster RL, Chen HY, Trumbauer M (1981) Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27: 223–231
Brinster RL, Chen HY, Trumbauer ME, Yagle MK, Palmiter RD (1985) Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci USA 82: 4438–4442
Clark AJ, Simons P, Wilmut I, Lathe R (1987) Pharmaceuticals from transgenic livestock. Trends Biotechnol 5: 20–24
Doetschman T, Gregg RG, Maeda N, Hooper ML, Melton DW, Thompson S, Smithies O (1987) Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330: 576–578
Gannon F (1986) Transgenics. In: Smith C, King JWB, McKay JC (eds) Exploiting new technologies in animal breeding: genetic developments. Oxford University Press, Oxford, pp 54–58
Gordon K, Lee E, Vitale JA, Smith AE, Westphal H, Hennighausen L (1987) Production of human tissue plasminogen activator in transgenic mouse milk. Bio Technology 5: 1183–1187
Gossler A, Doetschman T, Korn R, Serfling E, Kemler R (1986) Transgenesis by means of blastocyst-derived stem cell lines. Proc Natl Acad Sci USA 83: 9065–9069
Hammer RE, Pursel VG, Rexroad CE Jr, Wall RJ, Bolt DJ, Ebert KM, Palmiter RD, Brinster RL (1985) Production of transgenic rabbits, sheep and pigs by microinjection. Nature 315: 680–683
Izant JG, Weintraub H (1984) Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis. Cell 36: 1007–1015
Jähner D, Kirsten H, Mulligan R, Jaenisch R (1985) Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection. Proc Natl Acad Sci USA 82: 6927–6931
Kim SK, Wold BJ (1985) Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA. Cell 42: 129–138
Kuehn MR, Bradley A, Robertson EJ, Evans MJ (1987) A potential animal model for LeschNyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295–298
Lathe R, Clark AJ, Archibald AL, Bishop JO, Simons P, Wilmut I (1986) Novel products from livestock. In: Smith C, King JWB, McKay JC (eds) Exploiting new technologies in animal breeding: genetic developments. Oxford University Press, Oxford, pp 91–102
Lee K-F, DeMayo FJ, Atiee SH, Rosen JM (1988) Tissue-specific expression of the rat ß-casein gene in transgenic mice. Nucl Acids Res 16: 1027–1041
Mercier J-C (1986) Genetic engineering applied to milk producing animals: some expectations. In: Smith C, King JWB, McKay JC (eds) Exploiting new technologies in animal breeding: genetic developments. Oxford University Press, Oxford, pp 122–131
Palmiter RD, Brinster RL (1986) Germline transformation of mice. Ann Rev Genet 20: 465 —499
Robertson E, Bradley A, Kuehn M, Evans M (1986) Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323: 445–448
Schmidt DG (1982) Association of caseins and casein micelle structure. In: Fox PF (ed) Developments in dairy chemistry, vol 1, proteins. Applied Science Publishers, London and New York, pp 61–86
Simons JP, Land RB (1987) Transgenic livestock. J Reprod Fertil [Suppl] 34: 237–250
Simons JP, McClenaghan M, Clark AJ (1987) Alteration of the quality of milk by expression of sheep ß-lactoglobulin in transgenic mice. Nature 328: 530–532
Simons JP, Wilmut I, Clark AJ, Archibald AL, Bishop JO, Lathe R (1988) Gene transfer into sheep. Bio Technology 6: 179–183
Thomas KR, Capecchi MR (1987) Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51: 503–512
van der Putten H, Botteri FM, Miller AD, Rosenfeld MG, Fan H, Evans RM, Verma IM (1985) Efficient insertion of genes into the mouse germ line via retroviral vectors. Proc Natl Acad Sci USA 82: 6148–6152
Wall RJ, Pursel VG, Hammer RE, Brinster RL (1985) Development of porcine ova that were centrifuged to permit visualization of pronuclei and nuclei. Biol Reprod 32: 645–651
Walstra P, Jenness R (1984) Dairy chemistry and physics. Wiley, New York
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© 1989 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
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Simons, J.P. (1989). Modification of Milk by Gene Transfer. In: Barth, C.A., Schlimme, E. (eds) Milk Proteins. Steinkopff. https://doi.org/10.1007/978-3-642-85373-9_18
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DOI: https://doi.org/10.1007/978-3-642-85373-9_18
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