Evidence of myocyte hyperplasia in hypertrophic cardiomyopathy and other disorders with myocardial hypertrophy?
The mechanisms that mediate the increase in cardiac mass which occurs in patients with hypertrophic cardiomyopathy remain uncertain. The disease is characterized microscopically by an increase in the size of the myocytes, which often show a bizarre type of cellular and intracellular disarray, and by an increase in the amount of interstitial fibrous connective tissue (35). It is considered that the greatest contribution to the increased cardiac mass is made by the myocytes. Nevertheless, it is not clear at the present time whether this is mediated not only by an increase in the size of the cells (hypertrophy) but also by an increase in the number of cells (hyperplasia) or by a combination of these two factors. This question is particularly relevant to the process of asymmetric hypertrophy that affects the ventricular septum in hypertrophic cardiomyopathy. Before considering this question in detail, it is convenient to review our knowledge of the mechanisms involved in hypertrophy and hyperplasia of cardiac myocytes.
KeywordsCardiac Myocytes Hypertrophic Cardiomyopathy Cardiac Mass Diabetic Mother Atrial Myocytes
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