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Long-term treatment of hypertrophic cardiomyopathy with verapamil or propranolol in matched pairs of patients: Results of a multicenter study

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New Aspects of Hypertrophic Cardiomyopathy

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Abstract

According to definition, hypertrophic cardiomyopathy (HCM) is a myocardial disease of unknown origin. Initially, types with and without obstruction of the left or right ventricle were separated as different diseases.

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References

  1. Harrison D, Braunwald E, Glich G, Mason DT, Chidsey CA, Ross J Jr (1964) Effects of 13adrenergic blockade on the circulation with particular reference to observations in patients with hypertrophic subaortic stenosis. Circulation 29: 84

    PubMed  CAS  Google Scholar 

  2. Lösse B, Kuhn H, Loogen F (1982) Functional results in medically and surgically treated patients with hypertrophie obstructive cardiomyopathy. In: Kaltenbach M, Epstein SE (eds), Hypertrophic Cardiomyopathy. Springer Berlin—Heidelberg—New York, pp, 251–260

    Google Scholar 

  3. Kuhn H, Loogen F (1978) Die Anwendung von Beta-Rezeptorenblockern bei hypertrophischer Kardiomyopathy ( HOCM ). Internist 19: 527–531

    Google Scholar 

  4. Kober G, Schmidt-Moritz A, Hopf R, Kaltenbach M (1983) Long-term treatment of hypertrophic obstructive cardiomyopathy — usefulness of verapamil. Eur Heart J 4: 165–174

    PubMed  Google Scholar 

  5. Hopf R, Rodrian S, Kaltenbach M (1986) Behandlung der hypertrophen Kardiomyopathy mit Kalziumantagonisten. Therapiewoche 36: 1433–1454

    Google Scholar 

  6. Lösse B, Kuhn H, Loogen F (1982) Klinische und hämodynamische Effekte von Verapamil bei hypertrophischer obstruktiver Kardiomyopathie. Z Kardiol 71: 813–819

    PubMed  Google Scholar 

  7. Maron BJ, Merill, WH, Freier PA, Kent KM, Epstein SE, Morrow AG (1978) Long-term clinical course and symptomatic status of patients after operation for hypertrophie subaortic stenosis. Circulation 57: 1205–1213

    PubMed  CAS  Google Scholar 

  8. Agnew TM, Barratt-Boyes BG, Brandt PWT, Roche AHG, Lowe JB, O’Brien KP (1977) Surgical resection in idiopathic hypertrophie subaortic stenosis with a combined approach through aorta and left ventricle: a long-term follow-up study in 49 patients. J Thor Cardiovasc Surg 74: 307–316

    CAS  Google Scholar 

  9. Bonow RO, Rosing DR, Bacharach SL, Green MV, Kent KM, Lipson LC, Maron BJ, Leon MB, Epstein SE (1981) Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 64: 787–796

    Article  PubMed  CAS  Google Scholar 

  10. Landmark K, Sire S, Thaulow E, Amlie JP, Nitter-Hauge S (1982) Hemodynamic effects of nifedipine and propranolol in patients with hypertrophie obstructive cardiomyopathy. Br Heart J 48: 19–26

    Article  PubMed  CAS  Google Scholar 

  11. Stenson RE, Flamm MD Jr, Harrison DC, Hancock EW (1973) Hypertrophie subaortic stenosis. Clinical and hemodynamic effects of long-term propranolol therapy. Am J Cardiol 31: 763–773

    Google Scholar 

  12. Schmid P, Pavek P, Klein W (1979) Echokardiographische und hämodynamische Untersuchungen zur Beeinflussung der hypertrophischen obstruktiven Kardiomyopathie durch Verapamil. Z Kardiol 68: 89–92

    PubMed  CAS  Google Scholar 

  13. Vincenzi M, Morlino T, Allegri P, Barbierei E, Cappelletti F, de Lio U, Ometto R, Maiolino P (1981) Changes in cardiovascular function induced by verapamil in healthy subjects and in patients with ischemic heart disease. Clin Cardiol 4: 15–21

    Article  PubMed  CAS  Google Scholar 

  14. Spicer RL, Rocchini AP, Crowley DC, Vasiliades J, Rosenthal A (1983) Hemodynamic effects of verapamil in children and adolescents with hypertrophie cardiomyopathy. Circulation 67: 413–420

    Article  PubMed  CAS  Google Scholar 

  15. Rosing DR, Kent KM, Borer JS, Seides SF, Maron BJ, Epstein SE (1979) Verapamil therapy: a new approach to the pharmacologie treatment of hypertrophie cardiomyopathy. I. Hemodynamic effects. Circulation 60: 1201–1207

    Google Scholar 

  16. Rosing DR, Kent KM, Maron BJ, Epstein SE (1979) Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophie cardiomyopathy. II. Effects on exercise capacity and symptomatic status. Circulation 60: 1208–1213

    Google Scholar 

  17. Senn M, Hess OM, Krayenbühl HP (1982) Nifedipin in der Behandlung der hypertrophen, nichtobstruktiven Kardiomyopathie. Schweiz Med Wschr 112: 1312–1317

    PubMed  CAS  Google Scholar 

  18. Hanrath P, Mathey DG, Kremer P, Sonntag F, Bleifeld W (1980) Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophic cardiomyopathy. Am J Cardiol 45: 1258–1264

    Article  PubMed  CAS  Google Scholar 

  19. Frank MJ, Abdulla AM, Canedo MI, Saylors RE (1978) Long-term medical management of hypertrophic obstructive cardiomyopathy. Am J Cardiol 42: 993–1001

    Article  PubMed  CAS  Google Scholar 

  20. Canedo MI, Frank MJ (1981) Therapy of hypertrophic cardiomyopathy: medical or surgical? Clinical and pathophysiologic considerations. Am J Cardiol 48: 383–388

    Article  PubMed  CAS  Google Scholar 

  21. Wigle ED, Adelman AG, Felderhof CH (1974) Medical and surgical treatment of the cardiomyopathies. Circ Res 34, 35 Suppl II: 198–223

    Google Scholar 

  22. Goodwin JF (1974) Prospects and predictions for the cardiomyopathies. Circulation 50: 210–219

    PubMed  CAS  Google Scholar 

  23. Loogen F, Krelhaus W, Kuhn H (1976) Verlaufsbeobachtungen der hypertrophischen obstruktiven Kardiomyopathie ( HOCM ). Z Kardiol 65: 511–521

    Google Scholar 

  24. Kaltenbach M, Hopf R (1982) Konservative medikamentöse Behandlung der hypertrophen Myokardiopathie. Z Kardiol 71: 795–805

    PubMed  CAS  Google Scholar 

  25. Kaltenbach M, Hopf R, Kober G, Bussmann WD, Keller M, Petersen Y (1979) Treatment of hypertrophic obstructive cardiomyopathy with verapamil. Br Heart J 42: 35–42

    Article  PubMed  CAS  Google Scholar 

  26. Kaltenbach M, Hopf R, Keller M (1976) Calciumantagonistische Therapie bei hypertroph obstructiver Kardiomyopathie. Dtsch Med Wschr 101: 1284–1287

    Article  PubMed  CAS  Google Scholar 

  27. Masini V, Ceci V, Malinconico U, Milazotto F (1981) Therapeutic evaluation of pindolol and verapamil in hypertrophic obstructive cardiomyopathy. G Ital Cardiol II: 1729–1737

    Google Scholar 

  28. Haberer T, Hess OM, Jenni R, Krayenbühl HP (1983) Hypertrophe obstruktive Kardiomyopathie: Spontanverlauf im Vergleich zu Langzeittherapie mit Propranolol und Verapamil. Z Kardiol 72: 487–493

    Google Scholar 

  29. Shand DG (1975) Drug therapy: propranolol. N Engl J Med 293: 280–285

    Article  PubMed  CAS  Google Scholar 

  30. Chidsey C, Pine M, Favrot L, Smith S, Leonetti G, Morselli P, Zanchetti A (1976) The use of drug concentration measurements in studies of the therapeutic responses to propranolol. Postgr Med J 52 (S4): 26–32

    CAS  Google Scholar 

  31. Vucovich RA, Foley JE, Brown B, Willard DA, Buckley MO, Kelly D, Fitzgerald D, Torney W, Darragh A (1979) Effect of ß-blockers on exercise double product (systolic blood pressure X heart rate). Br J Clin Pharmacol 7 (Suppl 2): 167–172

    Google Scholar 

  32. Brody DA (1956) Theoretical analysis of intracavitory blood mass influence on the heart-lead relationship. Circ Res 4: 731

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Zentrum der Inneren Medizin, Abteilung für Kardiologie, Universitätsklinikum Frankfurt, Germany

    Prof. Dr. med. G. Kober, R. Hopf & M. Kaltenbach

  2. Universitätsklinikum Steglitz, Berlin, Germany

    G. Biamino

  3. Benedikt Kreutz-Rehabilitationszentrum Bad Krozingen, Germany

    P. Bubenheimer

  4. Kerckhoff-Klinik Bad Nauheim, Germany

    K. Förster & M. Schlepper

  5. Kardiologische Abteilung, II. Medizinische Universitätsklinik, Hamburg, Germany

    K. H. Kuck & P. Hanrath

  6. Medizinische Klinik, Abteilung Innere Medizin III, Universität Heidelberg, Germany

    K.-E. v. Olshausen

  7. Abteilung für Kardiologie, Zentrum der Inneren Medizin, Klinikum der Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt am Main, Germany

    Prof. Dr. med. G. Kober

Authors
  1. Prof. Dr. med. G. Kober
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  2. R. Hopf
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  3. G. Biamino
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  4. P. Bubenheimer
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  5. K. Förster
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  6. K. H. Kuck
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  7. P. Hanrath
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  8. K.-E. v. Olshausen
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  9. M. Schlepper
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  10. M. Kaltenbach
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Editor information

Editors and Affiliations

  1. Abteilung Kardiologie, Zentrum Innere Medizin, Theodor-Stern-Kai 7, 6000, Frankfurt 70, Germany

    M. Kaltenbach  & R. Hopf  & 

  2. Medizinische Poliklinik, Universität Erlangen, Östliche Stadtmauerstraße 29, 8520, Erlangen, Germany

    B. Kunkel

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© 1988 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Kober, G. et al. (1988). Long-term treatment of hypertrophic cardiomyopathy with verapamil or propranolol in matched pairs of patients: Results of a multicenter study. In: Kaltenbach, M., Hopf, R., Kunkel, B. (eds) New Aspects of Hypertrophic Cardiomyopathy. Steinkopff. https://doi.org/10.1007/978-3-642-85369-2_19

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  • DOI: https://doi.org/10.1007/978-3-642-85369-2_19

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85371-5

  • Online ISBN: 978-3-642-85369-2

  • eBook Packages: Springer Book Archive

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