Abstract
An improvement in diastolic filling has been reported after administration of calcium-blocking agents in patients with hypertrophic cardiomyopathy. This effect was attributed to improved left ventricular relaxation and increased early diastolic filling (1, 4–8). The mode of action of the calcium-blockers is, however, not clear, but certainly involves an inhibition of the calcium influx into the muscle cell. A reduction in intracellular cytosolic calcium is thought to be responsible for an improved rate of relaxation in patients with hypertrophic cardiomyopathy. An increase in intracellular calcium is known to be associated with increased contractility and decreased rate of relaxation, as has been reported in the papillary muscle (10). The purpose of the present study was, therefore, to evaluate the effect of verapamil on left ventricular relaxation and diastolic filling in patients with hypertrophic cardiomyopathy and to compare these effects with the response to verapamil in patients with secondary myocardial hypertrophy due to aortic stenosis.
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© 1988 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
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Hess, O.M., Murakami, T., Krayenbühl, H.P. (1988). Influence of verapamil on diastolic left ventricular function in myocardial hypertrophy of different origin. In: Kaltenbach, M., Hopf, R., Kunkel, B. (eds) New Aspects of Hypertrophic Cardiomyopathy. Steinkopff. https://doi.org/10.1007/978-3-642-85369-2_14
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DOI: https://doi.org/10.1007/978-3-642-85369-2_14
Publisher Name: Steinkopff
Print ISBN: 978-3-642-85371-5
Online ISBN: 978-3-642-85369-2
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