Abstract
An increase in the activity of the adrenergic nervous system is one of the features of mild hypertension and is thought to contribute to the mechanism of the disease (De Quatro and Chan 1972; Champlain et al. 1981). Both hypertension and augmented sympathetic drive help to produce the symptoms of angina pectoris by increasing afterload and accelerating metabolic rate, respectively. Each of these mechanisms raises the oxygen demand of the heart muscle and is likely to lead to a shortage of oxygen, which is known to trigger coronary pain.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ceremuzynski L, Lada J, Maruchin M, Dluzniewski M, Herbaczynska-Cedro K (1979a) Suppression of catecholamine excretion by low doses of clonidine in healthy subjects and feasibility study on clonidine application in angina pectoris. Drug Res 5: 829–835.
Ceremuzynski L, Zaleska T, Lada W, Zalewski A (1979b) Clonidine effect in chronic angina pectoris. Double-blind, crossover trial on 60 patients. Eur J Cardiol 10: 415–427.
Challoner DR, Steinberg D (1966) Oxidative metabolism of myocardium as influenced by fatty acids and epinephrine. Am J Physiol 211: 897–902.
Champlain J, Cousineau D, Lapointe L, Lavalee M, Nadean R, Denis G (1981) Sympathetic abnormalities in human hypertension. Clin Exp Hypertension 3: 417–438.
De Quattro V, Chan S (1972) Raised plasma catecholamines in some patients with primary hypertension. Lancet 11: 806–809.
Finney DJ, Latscha R, Benett BM, Hsu P (1963) Tables for testing significance in a 2×2 contingency table. Cambridge University Press, Cambridge.
Górny D (1964) Fluorimetric determination of free adrenaline and noradrenaline in urine (in Polish). Pol Tyg Lek 19: 632–635.
Kobinger W, Walland A (1967) Investigations into the mechanisms of the hypotensive effect of 2-(2,6-dichlorophenylamino)-2-imidazoline HCI. Eur J Pharmacol 2: 155–162.
Mueller HS, Ayres SM (1978) Metabolic responses of the heart in acute myocardial infarction in man. Am J Cardiol 42: 363–371.
Raab W (1963) The nonvascular metabolic myocardial vulnerability factor in “coronary heart disease”. Am Heart J 66: 685–706.
Schmitt H, Schmitt H, Boissier JR, Giudicelli JF (1967) Centrally mediated decrease in sympathetic tone induced by 2-(2,6-dichlorophenylamino)-2-imidazoline (ST 155, Catapresan ). EurJ Pharmacol 2: 147–148.
von Euler US, Lishajko F (1959) The estimation of catecholamines in urine. Acta Physiol Scand 45: 122–132.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
About this paper
Cite this paper
Zaleska, T., Ceremużyński, L. (1984). Clonidine for treating patients with mild hypertension and angina pectoris. In: Weber, M.A., Mathias, C.J. (eds) Mild Hypertension. Steinkopff. https://doi.org/10.1007/978-3-642-85334-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-85334-0_12
Publisher Name: Steinkopff
Print ISBN: 978-3-642-85336-4
Online ISBN: 978-3-642-85334-0
eBook Packages: Springer Book Archive