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Sympathetic nervous system activity in the obese hypertensive patient: potential role for central alpha-adrenoreceptor agonists

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Mild Hypertension

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Abstract

In most industrialized populations a strong association between blood pressure and body weight has been established. Several large-scale studies in the United States have confirmed the relationship between obesity and hypertension (the Framingham Study (Kannel et al. 1967); the Evans Country, Georgia Study (Tyroler et al. 1975); the Community Hypertension Evaluation Clinic (Stamler et al. 1978); Hypertensive Detection and Follow-up Program Cooperative Group (1979)). In the Evans county, Georgia study it was demonstrated prospectively that weight gain can increase blood pressure. Over the six-year period of the study, weight gain was associated with a two-fold possibility of developing hypertension. The converse was also true: subjects who were hypertensive at outset gained more weight. In those who were both obese and hypertensive at the outset, a weight reduction programme averaging 8 kg per patient produced very pronounced decrements in both systolic and diastolic blood pressure over a year. Comparing black and white subjects, it was concluded that obese white hypertensives benefited more than blacks from weight loss.

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Author information

Authors and Affiliations

  1. Chief of Endocrinology and Metabolism VA Medical Center, 16111 Plummer St., 91343, Sepulveda, CA, USA

    Michael Tuck M.D.

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  1. Michael Tuck M.D.
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Editor information

Editors and Affiliations

  1. Hypertension Center, Veterans Administration Center, 5901 East 7th Street, 90822, Long Beach, California, USA

    M. A. Weber

  2. Medical Unit, St. Mary’ Hospital Medical School, Norfolk Place, W2 1PG, London, Great Britain

    C. J. Mathias M. B., B. S., D. Phil., M. R. C. P. (Senior Wellcome Fellow in Clinical Science, Honorary Consultant Physician and Senior Lecturer in Medicine) (Senior Wellcome Fellow in Clinical Science, Honorary Consultant Physician and Senior Lecturer in Medicine)

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© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Tuck, M. (1984). Sympathetic nervous system activity in the obese hypertensive patient: potential role for central alpha-adrenoreceptor agonists. In: Weber, M.A., Mathias, C.J. (eds) Mild Hypertension. Steinkopff. https://doi.org/10.1007/978-3-642-85334-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-85334-0_11

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85336-4

  • Online ISBN: 978-3-642-85334-0

  • eBook Packages: Springer Book Archive

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