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Latent hyperuricemia and hyperuricosuria—a risk factor for stone formation—diagnosis with a purine-loading test

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Abstract

Increased uric acid in serum as a result of animal protein overconsumption and alcohol abuse is frequent nowadays. Concentrations above 6,5 mg uric acid/100 ml serum can lead to the deposition of uric acid or its salts in tissues, which in turn can lead to gout. Up to 40% of the patients suffering from gout also have uric acid nephrolithiasis. Without showing the symptoms of gout, however, uric acid stones as well as urate stones can form when the solubility product is exceeded either because of extreme uricosuria and/or because of an unfavorable urinary pH. About 20% of all urinary stones are totally or partially composed of uric acid or urate.

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References

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O. Sperling W. Vahlensieck

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© 1981 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Hesse, A., Schneeberger, W., Bach, D., Dewes, W., Vahlensieck, W. (1981). Latent hyperuricemia and hyperuricosuria—a risk factor for stone formation—diagnosis with a purine-loading test. In: Sperling, O., Vahlensieck, W. (eds) Uric acid lithiasis. Fortschritte der Urologie und Nephrologie/Advances in Urology and Nephrology, vol 16. Steinkopff. https://doi.org/10.1007/978-3-642-85318-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-85318-0_15

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0594-0

  • Online ISBN: 978-3-642-85318-0

  • eBook Packages: Springer Book Archive

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