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Das Arterielle System pp 338–343Cite as

Vergleichende Untersuchungen über die mikrosomale Ca-ATPase und die alkalische Phosphatase des Herzmuskels

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Part of the book series: Verhandlungen Der Deutschen Gesellschaft für Kreislaufforschung ((2849,volume 40))

Zusammenfassung

Nach enzymhistochemischen Untersuchungen am Hundeherzen ist die Aktivität der alkalischen Phosphatase (AP) auf das Endothel und die glatte Gefäßmuskulatur der koronaren Widerstandsgefäße beschränkt (1). Eine Funktion dieser AP ist nicht bekannt. An einigen Zellorganellen wurde die AP mit der Ca++-stimulierbaren ATPase und dem Ca++-Transport in Zusammenhang gebracht, so am Btirstensaum des Dünndarmes (9, 17, 19), am Knochen und an Mikrosomen aus der glatten Muskulatur der Aorta (14). Die Gefäßmikrosomen setzen unter Angiotensin Ca++ frei, die AP und die Ca++-ATPase werden gehemmt. Der Angiotensineffekt ist durch Theophyllin und cAMP umkehrbar.

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Literatur

  1. Borgers, M., J. Schaper, and W. Schaper, Localization of specific phosphatase activities in canine coronary blood vessels and heart muscle. J. Histochem. Cytochem. 19, 526–539 (1971).

    Article  PubMed  CAS  Google Scholar 

  2. Borgers, M., J. Schaper, and W. Schaper, Adenosine-producing sites in the mammalian heart: a cytochemical study. J. Mol. Cell. Cardiol. 3, 287–296 (1971).

    Article  PubMed  CAS  Google Scholar 

  3. Conyers, R. A. J., D. J. Birkett, F. C. Neale, S. Posen, and J. Brudenell- Woods, The action of EDTA on human alkaline phosphatases Biochim. Biophys. Acta 139, 363–371 (1967).

    CAS  Google Scholar 

  4. Dietze, G., and K. D. Hepp, Calcium stimulated ATP-ase of cardiac sarcolemma. Biochem. Biophys. Res. Comm. 44, 1041– 1049 (1971).

    Article  PubMed  CAS  Google Scholar 

  5. Dietze, G., and K. D. Hepp, Effect of 3’, 5’-AMP on calcium -activated ATP-ase in rat heart sarcolemma. Biochem. Biophys. Res. Comm. 46, 269–278 (1972).

    Article  PubMed  CAS  Google Scholar 

  6. Fleckenstein, A., Neuere Ergebnisse zur Physiologie, Pharmakologie und Pathologie der elektromechanischen Koppelungsprozesse im Warmblütermyokard. Vorträge der Erlanger Physiologentagung 1970, Hrsg. W. D. Keidel und K. H Plattig, (Berlin, Heidelberg, New York 1971).

    Google Scholar 

  7. v. Funcke, H. J., G. Dietze, and K. D. Hepp, Studies on the positive inotropic action of catecholamines. Eur. J. Clin. Invest. 3, Nr. 3, 230 (1973).

    Google Scholar 

  8. v. Funcke, H J., G. Dietze, and K. D. Hepp, Calcium-activated ATP-ase of cardiac sarcolemma: biochemical and morphological characteristics. 9th Intern. Congress Biochem. Stockholm, 1.–7.7. 1973, Abstract book, 5d6.

    Google Scholar 

  9. Haussler, M. R., L. A. Nagode, and H. Resmussen, Induction of intestinal brush border alkaline phosphatase by Vitamin D and identity with Ca-ATPase. Nature 288, 1199–1201 (1970).

    Article  Google Scholar 

  10. Hepp, K. D., Adenylate Cyclase and Insulin action. Effect of insulin, nonsuppressible insulin- like material, and diabetes on adenylate-cyclase activity in mouse liver. Eur. J. Biochem. 31, 266–276 (1972).

    Article  PubMed  CAS  Google Scholar 

  11. Hove, E., C. A. Elvehjem, and E. B. Hart, The effect of zinc on alkaline phosphatase. J. biol. Chem. 66, 425 (1940).

    Google Scholar 

  12. Inesi, G, p-nitrophenylphosphate hydrolysis and calcium ion transport in fragmented carcoplasmic reticulum. Science 171, 901 (1971).

    Article  PubMed  CAS  Google Scholar 

  13. Iqbal, M., Effect of in vitro addition of zinc on alkaline phosphatase activity in the Zinc-deficient rat. Enzym. biol. clin. 11, 412–422 (1969).

    Google Scholar 

  14. Limas, C. J., and J. N. Cohen, Alkaline phosphatase in vascular smooth muscle. Nature new Biol. 245, 53–55 (1973).

    PubMed  CAS  Google Scholar 

  15. Manning, J. P., B. G. Steinetz, A. L. Babson, and M. C. Butler, A simple and reliable method for estimation of alkaline phosphatase in tissue homogenates. Enzymologia 31, 309–320 (1966).

    PubMed  CAS  Google Scholar 

  16. Müller, E., A. G. E. Pearse, and D. W. Moss, The inducible alkaline phosphatase of rat heart. Some properties of the enzyme and factors influencing its activity. Biochem. J. 123, 895–900 (1971).

    PubMed  Google Scholar 

  17. Norman, A. W., A. K. Mircheff, T. H. Adams, and A Spielvogel, Studies on the mechanism of action of calciferol. III. Vitamin-D-mediated increase of intestinal brush border alkaline phosphatase activity. Biochim. Biophys. Acta 215, 348–359 (1970).

    Article  PubMed  CAS  Google Scholar 

  18. Rega, A. F, D. E. Richards, and P. J. Garrahan, Calcium iondependent p-nitrophenyl phosphate phosphatase activity from human erythrocyte membranes. Biochem. J. 136, 185–194 (1973).

    PubMed  CAS  Google Scholar 

  19. Russell, R. G. G., A. Monod, J.-P. Bonjour, and H Fleisch, Relation between alkaline phosphatase and Ca-ATPase in calcium transport. Nature new Biol. 240, 126–127 (1972).

    Article  PubMed  CAS  Google Scholar 

  20. Sobel, B., E. Jequier, A. Sjoerdsma, and W. Lovenberg, Effect of catecholamines and adrenergic blocking agents on oxidative phosphorylation in rat heart mitochondria. Circulation Res. 19, 1050–1061 (1966).

    PubMed  CAS  Google Scholar 

  21. Sachs, L., Statistische Auswertungsmethoden. 3. Aufl. (Berlin, Heidelberg, New York, 1972).

    Google Scholar 

  22. Walter, K. und Ch. Schütt, Alkalische Phosphatase im Serum (fortlaufende Messung) in: Bermeier, H. U., Methoden der ezymatischen Analyse. 2. Aufl. (Wein/Bergstr., 1970), 823–826.

    Google Scholar 

  23. Williamson, J. R., Kinetic studies of epinephrine effects in the perfused rat heart. Pharmacol. Reviews 18, 205–213 (1966).

    CAS  Google Scholar 

  24. Wood, W. G., G. E. Lindenmayer, and A. Schwartz, Myocardial synthesis of ribonucleic acid. I. Stimulation by isoproterenol. J. Mol. Cell. Cardiol. 3, 127–138 (1971).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. III. Medinzinische Abt.,, Städtisches Krankenhaus München-Schwabing, Kölner Platz 1, 8 München 40, Deutschland

    Dr. H. J. v. Funcke, H. Reiner, G. Dietze, K. D. Hepp & H. Mehnert

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  1. Dr. H. J. v. Funcke
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  2. H. Reiner
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  3. G. Dietze
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  4. K. D. Hepp
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  5. H. Mehnert
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Editors and Affiliations

  1. Bad Nauheim, Deutschland

    Rudolf Thauer  & Klaus Pleschka  & 

  2. Giessen, Deutschland

    Rudolf Thauer  & Klaus Pleschka  & 

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© 1974 Dr. Dietrich Steinkopff Verlag, Darmstadt

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v. Funcke, H.J., Reiner, H., Dietze, G., Hepp, K.D., Mehnert, H. (1974). Vergleichende Untersuchungen über die mikrosomale Ca-ATPase und die alkalische Phosphatase des Herzmuskels. In: Thauer, R., Pleschka, K. (eds) Das Arterielle System. Verhandlungen Der Deutschen Gesellschaft für Kreislaufforschung, vol 40. Steinkopff. https://doi.org/10.1007/978-3-642-85290-9_57

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  • DOI: https://doi.org/10.1007/978-3-642-85290-9_57

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0416-5

  • Online ISBN: 978-3-642-85290-9

  • eBook Packages: Springer Book Archive

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