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Does mitogen-activated-protein kinase have a role in insulin action?

The cases for and against

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EJB Reviews

Part of the book series: European Journal of Biochemistry ((EJB REVIEWS,volume 1995))

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Abstract

The discovery of the mitogen-activated protein (MAP) kinase family of protein kinases has sparked off an intensive effort to elucidate their role in the regulation of many cellular processes. These protein kinases were originally identified based on their rapid activation by insulin. In this review we concentrate on examining the evidence for and against a role for the MAP kinases Erk-1 and Erk-2 in mediating the effects of insulin While there is good evidence in favour of a direct role for MAP kinase in the growth-promoting effects of insulin and the regulation of Glut-1 and c-fos expression, and AP-1 transcriptional complex activity, this is by no means conclusive. MAP kinase may also play a role in the control of mRNA translation by insulin. On the other hand, the evidence suggests that MAP kinase is not sufficient for the acute regulation of glucose transport (Glut-4 translocation), glycogen synthesis, acetyl-CoA carboxylase or pyruvate dehydrogenase activity. The findings suggest that insulin may utilise at least three distinct signalling pathways which do not involve MAP kinase.

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Abbreviations

MAP:

kinase, mitogen activated-protein kinase

EGF:

epidermal growth factor

PDGF:

platelet derived growth factor

IGF-1:

insulin-like growth factor-1

Erk:

extracellular signal regulated kinase

MAPKK:

mitogen activated protein kinase kinase

MAPKKK:

mitogenactivated protein kinase kinase kinase

IRS-1:

insulin receptor substrate-1

Ptdlns 3-kinase:

phosphatidylinositol 3-kinase

elF:

eukaryotic initiation factor

GSK-3:

glycogen synthase kinase-3

MAPKAP-K1:

mitogen-activated protein kinase-activated protein kinase-1

CHO:

Chinese hamster ovary

TPA:

O-tetra-decanoylphorbol 13-acetate

SH2:

src-homology 2

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Denton, R.M., Tavaré, J.M. (1995). Does mitogen-activated-protein kinase have a role in insulin action?. In: EJB Reviews. European Journal of Biochemistry, vol 1995. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85252-7_2

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