Abstract
Evidence from study of both normal and leukemic cells suggests that a crucial step in neutrophil maturation occurs in the transition from the promyelocyte to the myelocyte stage. The transition from the promyelocyte to the myelocyte in normal marrow cells is accompanied both by the loss of proliferative capacity associated with terminal maturation [1], and by the loss of the capacity for alternative maturation [2]. Normal promyelocytes respond to stimuli of both granulocyte and monocyte differentiation, but myelocytes are restricted to terminal granulocyte maturation [2]. In this regard, it is striking that acute myeloid leukemias invariably involve proliferation of cells arrested in development at or before the promyelocyte stage. Consequently, an understanding of the transition from the promyelocyte to the myelocyte stage should provide crucial insights into both the control mechanisms governing normal hematopoietic cell differentiation and the ways in which disruption of the control mechanisms can contribute to leukemic transformation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Janoshowitz H, Moore MAS, Metcalf D (1971) Density gradient segregation of bone marrow cells with the capacity to form granulocytic and macrophage colonies in vitro Exp Cell Res 68: 220–224
Warner HR, Athens JW (1964) Analysis of granulocyte kinetics in blood and bone marrow. Ann NY Acad Sci 113: 523–535
Bainton DF (1975) Neutrophil granules Br J Hematol 29: 17–22
Bainton DF, Ullyot JL, Farquhar MG (1971) The development of the neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 134: 907–34
Lomax KJ, Gallin JI, Benz EJ, Rado TA, Boxer LA, Malech HL (1989) Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency J Clin Invest 83: 514–519
Carmel R (1983) R-Binder deficiency: A clinically benign cause of cobalamin pseudodefi-ciency. J Amer Med Assoc 250: 1886–1890
Parmley RT, Tzeng DY, Baehner RL, Boxer LA (1983) Abnormal distribution of complex carbohydrates in neutrophils of a patient with lactoferrin deficiency. Blood 62: 538–548
Johnston J, Bollekens J, Allen RH, Berliner N (1989) Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein J Biol Chem 264:15754–15757
Devarajan P, Mookhtiar K, Van Wart H, Berliner N (1991) Structure and expression of the cDNA encoding human neutrophil collagenase Blood 77:2731–2738
Johnston J, Yang-Feng T, Berliner N (1991) Structure and mapping of the chromosomal gene encoding human transcobalamin I: Comparison to human intrinsic factor Genomics 12: 459–464
Johnston J, Rintels P, Chung J, Sather J, Benz EJ, Berliner N (1992) The lactoferrin gene promoter: Structural integrity and non-expression in HL60 cells Blood 79: 2998–3006
Devarajan P, Johnston J, Ginsberg S, Van Wart H, Berliner N (1992) Structure and expression of neutrophil gelatinase cDNA: Identity with Type IV collagenase from HT1080 cells J Biol Chem. 267: 25228–25232
Graubert T, Johnston J, Berliner N (1993) Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: Demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation. Blood 82: 3192–3197
Berliner N, Hsing A, Sigurdsson F, Zain M, Graubert T, Bruno E, Hoffman R (1995) G-CSF induction of normal human marrow progenitors results in neutrophil-specific gene expression. Blood 85:799–803
Collins SJ, Ruscett FW, Gallagher RE (1977) Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. Nature 270:347–349
Fibach E, Peled T, Treves A, Koraberg A, Rachmilewitz E (1982) Modulation of the maturation of human leukemic promyelocytes (HL-60) to granulocytes or macrophages Leukemia Res 6: 781–790
Miyauchi J, Watanabe Y, Enomoto Y, Takeuchi K (1983) Lactoferrin deficient polymorphonuclear leucocytes in leukemias: A semiquantitative and ultrastructural eytochemical study J Clin Pathol 36:1397–1405
Fearon ER, Burke PJ, Schiffer CA, Zehnbauer BA, Vogelstein B (1986) Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. N Engl J Med 315: 15–24
Khanna-Gupta A, Kolibaba K, Berliner N (1994) NB4 cells exhibit bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression Blood 84: 294–302
Johnston J, Boxer LA, Berliner N (1992) Correlation of RNA levels with protein deficiencies in specific granule deficiency. Blood 80: 2088–2091
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Khanna-Gupta, A., Zibello, T., Berliner, N. (1996). Coordinate Regulation of Neutrophil Secondary Granule Protein Gene Expression. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-85232-9_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-85234-3
Online ISBN: 978-3-642-85232-9
eBook Packages: Springer Book Archive