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Transgenic Models in the Study of AIDS Dementia Complex

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Book cover Transgenic Models of Human Viral and Immunological Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 206))

Abstract

A significant number of HIV-1 infected individuals develop central nervous system (CNS) complications which can include motor difficulties, behavioral abnormalities, and cognitive impairments. These symptoms can progress to nearly vegetative end stage clinical presentations of paralysis and severe dementia (see PRICE and PERRY 1994, for detailed review). Variably referred to as “AIDS dementia complex,” “HIV encephalopathy,” and “HIV-1 associated cognitive/motor complex,” this syndrome has been observed most often in the late stages of systemic HIV-1 infection. Nevertheless, the CNS is an early target of infection (Ho et al. 1985; Goudsmit et al. 1986; Marshall et al. 1988; Resnick et al. 1988; Appleman et al. 1988; Mcarthur et al. 1988; Elovaara et al. 1990). In pédiatric patients, CNS disease occurs more frequently and its accompanying clinical syndrome has been termed “progressive encephalopathy” (for review, see PRICE and PERRY 1994). The transgenic models discussed in this chapter are pertinent to both pédiatric and adult forms of HIV-1 -related brain damage.

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  1. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    S. M. Toggas & L. Mucke

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  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  2. Division of Experimental Pathology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  3. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

  4. Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

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Toggas, S.M., Mucke, L. (1996). Transgenic Models in the Study of AIDS Dementia Complex. In: Chisari, F.V., Oldstone, M.B.A. (eds) Transgenic Models of Human Viral and Immunological Disease. Current Topics in Microbiology and Immunology, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85208-4_12

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