Skip to main content

Virulenzfaktoren von Yersinia enterocolitica und die Immunantwort des Wirtes im experimentellen Mausinfektionsmodell

  • Conference paper
  • 43 Accesses

Zusammenfassung

Yersinia enterocolitica ist nach Salmonella sp. und Campylobacter sp. der häufigste Erreger bakterieller Enteritiden in Westeuropa. Die Übertragung von Y. enterocolitica auf den Menschen erfolgt hauptsächlich oral-alimentär durch kontaminierte Nahrungsmittel. Das wichtigste Erregerreservoir für den Menschen sind wahrscheinlich yersiniainfizierte Schweine.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Autenrieth IB, Tingle A, Reske-Kunz A, Heesemann J (1992) T lymphocytes mediate protection to Yersinia enterocolitica in mice: characterization of murine T cell clones specific for Yersinia enterocolitica. Infect Immun 3: 1140–1149

    Google Scholar 

  2. Autenrieth IB, Hantke K, Heesemann J (1991) Immunosuppression of the host and delivery of iron to the pathogen: a possible dual role of siderophores in the pathogenesis of microbial infections. Med Microbiol Immunol 180: 135–141

    Article  PubMed  CAS  Google Scholar 

  3. Autenrieth IB, Heesemann J (1992) In vivo neutralization of tumor necrosis factor alpha and gamma interferon abrogates resistance to Yersinia enterocolitica in mice. Med Microbiol Immunol 181: 333–338

    Article  PubMed  CAS  Google Scholar 

  4. Autenrieth IB, Hantschmann P, Heymer B, Heesemann J (1993a) Immunohistological characterization of the cellular immune response against Yersinia enterocolitica in mice: evidence for the involvement of T lymphocytes. Immunobiology 187: 1–16

    Article  PubMed  CAS  Google Scholar 

  5. Autenrieth IB, Beer M, Hantschmann P, Vogel U, Preger S, Heymer B, Heesemann J (1993b) The cellular immune response against Yersinia enterocolitica in different inbred strains of mice: evidence for an important role of T lymphocytes. Int J Med Microbiol Virol Parasitol Infect Dis 278: 383–395

    CAS  Google Scholar 

  6. Autenrieth IB, Vogel U, Preger S, Heymer B, Heesemann J (1993c) Experimental Yersinia enterocolitica infection in euthymic and athymic T cell deficient C57BL/6 nude mice: comparison of time course, histomorphology and immune response. Infect Immun 61: 2585–2595

    PubMed  CAS  Google Scholar 

  7. Autenrieth IB, Reissbrodt R, Saken E, Berner R, Vogel U, Rabsch W, Heesemann J (1994a) Desferrioxamine-promoted virulence of Yersinia enterocolitica in mice depends on both desferrioxamine type and mouse strain. J Infect Dis 169: 562–567

    Article  PubMed  CAS  Google Scholar 

  8. Autenrieth IB, Beer M, Bohne E, Kaufmann SHE, Heesemann J (1994b) Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role of interferon gamma. Infect Immun 62: 2590–2599

    PubMed  CAS  Google Scholar 

  9. Bäumler M, Koebnik R, Stjiljkovic I, Heesemann J, Braun V, Hantke K (1993) Iron uptake systems of Yersinia enterocolitica — a survey. Zentralbl Bakt 278: 416–424

    Article  Google Scholar 

  10. Bohn E, Heesemann J, Ehlers S, Autenrieth IB (1994) Early IFn-g mRNA expression is associated with resistance of mice against Yersinia enterocolitica. Infect Immun 62: 3027–3032

    PubMed  CAS  Google Scholar 

  11. Brett SJ, Mazurov A, Charles I, Tite J (1994) The invasin protein of Yersinia spp. provides co-stimulatory activity to humanT cells through interaction with ß1 integrins. Eur J Immunol 23: 1608–1614

    Article  Google Scholar 

  12. Carter P (1975) Pathogenicity of Yersinia enterocolitica for mice. Infect Immun 11: 164–170

    PubMed  CAS  Google Scholar 

  13. Cornelis G, Laroche Y, Balligand G, Sory M,Wauters G (1987) Yersinia enterocolitica, a primary model for bacterial invasiveness. Rev Infect Dis 9: 64–87

    CAS  Google Scholar 

  14. Cornelis G, Biot T, Lambert de Rouvroit C, Michiels T, Mulder B, Sluiters C, Sory M, van Bouchaute M, Vanooteghem J (1989) The YersiniaYop regulon. Mol Microbiol 3: 1455–1459

    Article  CAS  Google Scholar 

  15. Cornelis G, Sluiters C, Delors I, Geib D, Kaniga K, Lambert des Rouvroit C, Sory M, Michiels T (1991) ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions. Mol Microbiol 5: 1023–1034

    Article  PubMed  CAS  Google Scholar 

  16. Delor I, Cornelis G (1992) Role of Yersinia enterocolitica Yst toxin in experimental infection of young rabbits. Infect Immun 60: 4269–4277

    PubMed  CAS  Google Scholar 

  17. Ewald JH, Heesemann J, Rüdiger H, Autenrieth IB (1994) Interaction of polymorphonuclear leukocytes with Yersinia enterocolitica: role of the Yersinia virulence plasmid and modulation by the iron-chelator desferrioxamine B. J Infect Dis 170: 140–150

    Article  PubMed  CAS  Google Scholar 

  18. Guan K, Dixon J (1990) Protein tyrosine phosphatase activity of an essential virulence determinant Yersinia. Science 249: 553–556

    Article  PubMed  CAS  Google Scholar 

  19. Haag H, Hantke K, Drechsel H, Stojiuljkovic I, Jung G, Zähner H (1993) Purification of Yersiniabactin: a siderophore and a possible virulence factor of Yersinia enterocolitica. J Gen Microbiol 139: 2159–2165

    PubMed  CAS  Google Scholar 

  20. Hahn H, Kaufmann SHE (1981) The role of cell-mediated immunity in bacterial infections. Rev Infect Dis 3: 1221–1250

    Article  PubMed  CAS  Google Scholar 

  21. Hancock G, Schaedler R, MacDonald TT (1986) Yersinia enterocolitica infections in resistant and susceptible strains of mice. Infect Immun 53: 26–31

    PubMed  CAS  Google Scholar 

  22. Hancock G, Schaedler W, MacDonald TT (1988) Multigenetic control of resistance against Yersinia enterocolitica in inbred strains of mice. Infect Immun 56: 532–533

    PubMed  CAS  Google Scholar 

  23. Hanski C, Kutschka U, Schmoranzer HP, Naumann M, Stallmach A, Hahn H, Menge H, Riecken E (1989) Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype 0:8 with intestinal mucosa during experimental enteritis. Infect Immun 57: 673–678

    PubMed  CAS  Google Scholar 

  24. Heesemann J (1987) Chromosomal encoded siderophores are required for mouse virulence of enteropathogenic Yersinia species. FEMS Microbiol Lett 48: 229–233

    Article  CAS  Google Scholar 

  25. Heesemann J, Gaede K (1989) Mechanisms involved in the pathogenesis of Yersinia infections. Rheumatol Int 9: 213–217

    PubMed  CAS  Google Scholar 

  26. Heesemann J, Grüter L (1987) Genetic evidenve that the outer membrane protein YPO1 of Yersinia enterocolitica mediates adherence and phagocytosis resistance to human epithelial cells. FEMS Microbiol Lett 40: 37–41

    Article  CAS  Google Scholar 

  27. Heesemann J, Hantke K, Vocke T, Saken E, Rakin A, Stlojiljkovic I, Berner R (1993) Virulence of Yersinia enterocolitica is closely associated with siderophore production, expression of an iron-repressible outer membrane polypeptide of 65,000 Da and pesticin sensitivity. Mol Microbiol 8: 397–408

    Article  PubMed  CAS  Google Scholar 

  28. Leung KY, Reisner B, Straley S (1990) YopM inhibits platalet aggregation and is necessary for virulence of Yersinia pestis in mice. Infect Immun 58: 3262–3271

    PubMed  CAS  Google Scholar 

  29. Lian C, Hwang W, Pai C (1987) Plasmid mediated resistance to phagocytosis in Yersinia enterocolitica. Infect Immun 55: 1176–1183

    PubMed  CAS  Google Scholar 

  30. Miller V, Falkow S (1988) Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells. Infect Immun 56: 1242–1248

    PubMed  CAS  Google Scholar 

  31. Miller V, Farmer J, Hill W, Falkow S (1989) The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease. Infect Immun 57: 121–131

    PubMed  CAS  Google Scholar 

  32. Miller V, Farmer J, Hill W, Falkow S (1989) The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease. Infect Immun 57: 121–131

    PubMed  CAS  Google Scholar 

  33. Pai C, De Stephano L (1982) Serum resistance associated with virulence in Yersinia enterocolitica. Infect Immun 35: 605–611

    PubMed  CAS  Google Scholar 

  34. Pilz D, Vocke T, Heesemann J, Brade V (1992) Mechanisms of YadA mediated serum resistance of Yersinia enterocolitica serotype 03. Infect Immun 60: 189–195

    PubMed  CAS  Google Scholar 

  35. Rabsch W, Reissbrodt R (1992) Eisenversorgung von Bakterien and ihre Bedeutung für den infektiösen Prozeß. Bioforum 15: 10–15

    Google Scholar 

  36. Robins-Brown R, Prpic J (1985) Effects of iron and desferrioxamine on infections with Yersinia enterocolitica. Infect Immun 47: 774–779

    Google Scholar 

  37. Rosqvist R, Bolin I, Wolf-Watz H (1988) Inhibition of phagocytosis in Yersinia pseudotuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein. Infect Immun 56: 2139–2143

    PubMed  CAS  Google Scholar 

  38. Rosqvist R, Forsberg A, Wolf-Watz H (1991) Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect Immun 59: 4562–4569

    PubMed  CAS  Google Scholar 

  39. Vogel U, Autenrieth IB, Berner R, Heesemann J (1993) Role of plasmid-encoded antigens of Yersinia enterocolitica in humoral Immunity against secondary Y. enterocolitica infection in mice. Microbial Pathogen 14: 1–14

    Article  Google Scholar 

  40. Young D (1992) Heat-shock proteins: immunity and autoimmunity. Curr Opin Immunol 4: 396–400

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Autenrieth, I.B. (1994). Virulenzfaktoren von Yersinia enterocolitica und die Immunantwort des Wirtes im experimentellen Mausinfektionsmodell. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85187-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58548-0

  • Online ISBN: 978-3-642-85187-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics