Abstract
In many respects, the development of systemic therapies for cancer has paralleled the development of antimicrobial therapy. The challenges and controversies that the pioneers in the development of systemic agents for the treatment of cancer met were similar to those the developers of antimicrobials encountered. For example, medical students in the 1920s were taught the reasons why “... any form of antibacterial chemotherapy...” was “... an impossible dream.” Respected medical researchers in the 1940s likened the challenge of finding an effective anticancer drug to the problem of finding an agent that would dissolve the left ear but leave the right ear unharmed.
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Coleman CN, Bump EA, Kramer RA (1988) Chemical modifiers of cancer treatment. Journal of Clinical Oncology 6: 709–733
Collins 3M (1984) Pharmacokinetic rationale for regional drug delivery. Journal of Clinical Oncology 2: 498–504
DeVita VT, Jr., Hellman S, Rosenberg SA (eds) (1985) Principles of chemotherapy. In: Cancer–principles and practice of oncology, 2nd edn. Lippincott, Philadelphia, pp 257–285
Goldie JH (1987) Scientific bases for adjuvant and primary (neoadjuvant) chemotherapy. Seminars in Oncology 14: 1–7
Goldie JH, Coleman AJ (1984) The genetic origin of drug resistance in neoplasms: implications for systemic therapy. Cancer Research 44: 3643–3653
Hryniuk W, Bush H (1984) The importance of dose density in chemotherapy of metastatic breast cancer. Journal of Clinical Oncology 2: 1281–1288
Moscan JA, Cowan KH (1988) Multi-drug resistance. Journal of the National Cancer Institute 80: 14–20
Schabel FM (1977) Rationale for adjuvant chemotherapy. Cancer 39:2875–2882
Schnipper LE (1986) Clinical implications of tumor cell heterogeneity. New England Journal of Medicine 314: 1423–1431
Weber G (1983) The biochemical strategy of cancer cells and the design of chemotherapy. Cancer Research 43: 3466–3492
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© 1994 Springer-Verlag Berlin Heidelberg
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Trump, D.L., Smith, D.C. (1994). Systemic Therapies. In: Love, R.R. (eds) Manual of Clinical Oncology. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85159-9_12
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DOI: https://doi.org/10.1007/978-3-642-85159-9_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58193-2
Online ISBN: 978-3-642-85159-9
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