Abstract
Cancer is a generic term used to describe over 200 individual diseases. These diseases progress differently over time but share certain characteristics. These characteristics include development within any tissue of a malignant growth derived from abnormal cells of the host. The abnormal cells proliferate autonomously, invade through normal tissue barriers, spread to local and distant tissue sites, and reproduce indefinitely. The masses of abnormal cells formed and spread in this way lead to the death of the host if not eradicated. (The word “cancer” comes from the Latin, meaning crab. A tumor was called a cancer because of swollen veins around the area resembling a crab’s limbs.)
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Further Reading
Druker BJ, Mamon HJ, Roberts TM (1989) Oncogenes, growth factors and signal transduction. New England Journal of Medicine 321: 1383–1391
Fearon ER, Vogelstein B (1990) A genetic model of colorectal tumorigenesis. Cell 61: 759–767
Hollingsworth RE, Lee WH (1991) Tumor suppressor genes: New prospects for cancer research. Journal of the National Cancer Institute 83:91–96
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Tannock IF, Hill RP (eds) (1993) The basic science of oncology. Pergamon, New York
Weinberg RA (1989) Oncogenes, anti-oncogenes and the molecular basis of multistep carcinogenesis. Cancer Research 49: 3713–3721
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© 1994 Springer-Verlag Berlin Heidelberg
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Love, R.R. (1994). Cellular and Molecular Biology of Cancer. In: Love, R.R. (eds) Manual of Clinical Oncology. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85159-9_1
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DOI: https://doi.org/10.1007/978-3-642-85159-9_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58193-2
Online ISBN: 978-3-642-85159-9
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