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Sodium Channel Specific Neurotoxins: Recent Advances in the Understanding of Their Molecular Mechanisms

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Selective Neurotoxicity

Part of the book series: Springer Study Edition ((SSE,volume 102))

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Abstract

The voltage-dependent sodium channel is a large transmembrane glycoprotein that mediates the sodium current during the action potential, a characteristic property of excitable cells (Hodgkin and Huxley 1952). A number of small molecules (<8 kDa) of diverse structure have quite specific effects on the physiological properties of the sodium channel by directly binding to the protein. These toxins, which have been extensively used for the molecular characterization of the sodium channel, include (a) those that inhibit ion transport, e.g., tetrodotoxin (TTX), (b) lipid-soluble activators of the sodium channel, e.g., batrachotoxin (BTX), (c) the North African α- scorpion toxins, e.g., Leiurus quinquestriatus toxin, (d) the American (β- scorpion toxins, e.g., Tityus toxin, (e) ciguatoxin and brevetoxin (see Table1 and Fig. 1).

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Authors
  1. S. Becker
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  2. R. D. Gordon
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Editors and Affiliations

  1. Institut für Pharmakologie, Freien Universität, Thielallee 69/73, 14195, Berlin, Germany

    Hans Herken

  2. Institut für Biochemie, Freien Universität, Thielallee 63, 14195, Berlin, Germany

    Ferdinand Hucho

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Becker, S., Gordon, R.D. (1994). Sodium Channel Specific Neurotoxins: Recent Advances in the Understanding of Their Molecular Mechanisms. In: Herken, H., Hucho, F. (eds) Selective Neurotoxicity. Springer Study Edition, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85117-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-85117-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57815-4

  • Online ISBN: 978-3-642-85117-9

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