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Selective Neurotoxicity pp 577–610Cite as

Peptide Toxins Acting on the Nicotinic Acetylcholine Receptor

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Part of the book series: Springer Study Edition ((SSE,volume 102))

Abstract

Ever since Claude Bernard identified the neuromuscular junction as the site of action of the arrow poison curare (Bernard 1857), neurotoxins have been at the focus of interest for researchers investigating the mechanisms of propagation and transmission of nerve impulses. Neurotoxins turned out to be very valuable tools in these investigations (Mebs and Hucho 1990; Hucho and Ovchinnikov 1983). They are currently used for elucidating the proteins of nerve and muscle membranes with atomic resolution.

Work from the lab included in this review was supported by the Deutsche Forschungsgemeinschaft (SfB 312) and the Fonds der Chemischen Industrie.

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  1. Institut für Pharmakologie, Freien Universität, Thielallee 69/73, 14195, Berlin, Germany

    Hans Herken

  2. Institut für Biochemie, Freien Universität, Thielallee 63, 14195, Berlin, Germany

    Ferdinand Hucho

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Hucho, F. (1994). Peptide Toxins Acting on the Nicotinic Acetylcholine Receptor. In: Herken, H., Hucho, F. (eds) Selective Neurotoxicity. Springer Study Edition, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85117-9_16

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